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• W2945667776 endingPage "97" @default.
• W2945667776 startingPage "90" @default.
• W2945667776 abstract "Background There has been recent interest in nonproton MRI including hyperpolarized carbon-13 (13C) imaging. Prostate cancer has been shown to have a higher tissue sodium concentration (TSC) than normal tissue. Sodium (23Na) and 13C nuclei have a frequency difference of only 1.66 MHz at 3T, potentially enabling 23Na imaging with a 13C-tuned coil and maximizing the metabolic information obtained from a single study. Purpose To compare TSC measurements from a 13C-tuned endorectal coil to those quantified with a dedicated 23Na-tuned coil. Study Type Prospective. Population Eight patients with biopsy-proven, intermediate/high risk prostate cancer imaged prior to prostatectomy. Sequence 3T MRI with separate dual-tuned 1H/23Na and 1H/13C endorectal receive coils to quantify TSC. Assessment Regions-of-interest for TSC quantification were defined for normal peripheral zone (PZ), normal transition zone (TZ), and tumor, with reference to histopathology maps. Statistical Tests Two-sided Wilcoxon rank sum with additional measures of correlation, coefficient of variation, and Bland–Altman plots to assess for between-test differences. Results Mean TSC for normal PZ and TZ were 39.2 and 33.9 mM, respectively, with the 23Na coil and 40.1 and 36.3 mM, respectively, with the 13C coil (P = 0.22 and P = 0.11 for the intercoil comparison, respectively). For tumor tissue, there was no statistical difference between the overall mean tumor TSC measured with the 23Na coil (41.8 mM) and with the 13C coil (46.6 mM; P = 0.38). Bland–Altman plots showed good repeatability for tumor TSC measurements between coils, with a reproducibility coefficient of 9 mM; the coefficient of variation between the coils was 12%. The Pearson correlation coefficient for TSC between coils for all measurements was r = 0.71 (r2 = 0.51), indicating a strong positive linear relationship. The mean TSC within PZ tumors was significantly higher compared with normal PZ for both the 23Na coil (45.4 mM; P = 0.02) and the 13C coil (49.4 mM; P = 0.002). Data Conclusion We demonstrated the feasibility of using a carbon-tuned coil to quantify TSC, enabling dual metabolic information from a single coil. This approach could make the acquisition of both 23Na-MRI and 13C-MRI feasible in a single clinical imaging session. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:90–97." @default.
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• W2945667776 date "2019-05-13" @default.
• W2945667776 modified "2023-10-13" @default.
• W2945667776 title "Molecular imaging of the prostate: Comparing total sodium concentration quantification in prostate cancer and normal tissue using dedicated ¹³ C and ²³ Na endorectal coils" @default.
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• W2945667776 doi "https://doi.org/10.1002/jmri.26788" @default.
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