FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945668924> ?p ?o ?g. }

• W2945668924 endingPage "1078" @default.
• W2945668924 startingPage "1073" @default.
• W2945668924 abstract "The surface protein haemagglutinin (HA) of influenza A viruses (IAV) needs to be cleaved by a host protease to become functional. Here, we investigated if IAV of the H10 subtype also requires TMPRSS2 for replication and pathogenesis in mice. We first showed in cell culture that TMPRSS2 is able to cleave H10-HA. When Tmprss2−/− deficient mice were infected with a re-assorted virus H10-HA, they did not lose body weight and no viral replication was observed in contrast to wild-type mice. Histopathological analysis showed that inflammatory lesions in the lung of Tmprss2−/− mice were reduced compared to wild-type mice. In addition, no viral antigen was detected in the lungs of Tmprss2−/− mice and no evidence for HA cleavage was observed. We conclude from these studies that TMPRSS2 activity is also essential for in vivo replication and pathogenesis of H10 IAV." @default.
• W2945668924 created "2019-05-29" @default.
• W2945668924 creator A5004595481 @default.
• W2945668924 creator A5011711887 @default.
• W2945668924 creator A5031612388 @default.
• W2945668924 creator A5038499176 @default.
• W2945668924 creator A5052239466 @default.
• W2945668924 creator A5058634346 @default.
• W2945668924 creator A5068129579 @default.
• W2945668924 date "2019-07-01" @default.
• W2945668924 modified "2023-10-18" @default.
• W2945668924 title "Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis" @default.
• W2945668924 cites W1945881575 @default.
• W2945668924 cites W1964732021 @default.
• W2945668924 cites W1965400930 @default.
• W2945668924 cites W1972032770 @default.
• W2945668924 cites W1986710274 @default.
• W2945668924 cites W2002581355 @default.
• W2945668924 cites W2020316997 @default.
• W2945668924 cites W2056827251 @default.
• W2945668924 cites W2065550185 @default.
• W2945668924 cites W2084981497 @default.
• W2945668924 cites W2097102657 @default.
• W2945668924 cites W2102637313 @default.
• W2945668924 cites W2106842109 @default.
• W2945668924 cites W2149059384 @default.
• W2945668924 cites W2547765422 @default.
• W2945668924 cites W2887166156 @default.
• W2945668924 cites W2891542297 @default.
• W2945668924 cites W643879909 @default.
• W2945668924 doi "https://doi.org/10.1099/jgv.0.001274" @default.
• W2945668924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31099738" @default.
• W2945668924 hasPublicationYear "2019" @default.
• W2945668924 type Work @default.
• W2945668924 sameAs 2945668924 @default.
• W2945668924 citedByCount "25" @default.
• W2945668924 countsByYear W29456689242019 @default.
• W2945668924 countsByYear W29456689242020 @default.
• W2945668924 countsByYear W29456689242021 @default.
• W2945668924 countsByYear W29456689242022 @default.
• W2945668924 countsByYear W29456689242023 @default.
• W2945668924 crossrefType "journal-article" @default.
• W2945668924 hasAuthorship W2945668924A5004595481 @default.
• W2945668924 hasAuthorship W2945668924A5011711887 @default.
• W2945668924 hasAuthorship W2945668924A5031612388 @default.
• W2945668924 hasAuthorship W2945668924A5038499176 @default.
• W2945668924 hasAuthorship W2945668924A5052239466 @default.
• W2945668924 hasAuthorship W2945668924A5058634346 @default.
• W2945668924 hasAuthorship W2945668924A5068129579 @default.
• W2945668924 hasBestOaLocation W29456689241 @default.
• W2945668924 hasConcept C104317684 @default.
• W2945668924 hasConcept C140704245 @default.
• W2945668924 hasConcept C140933497 @default.
• W2945668924 hasConcept C142724271 @default.
• W2945668924 hasConcept C143065580 @default.
• W2945668924 hasConcept C159047783 @default.
• W2945668924 hasConcept C203014093 @default.
• W2945668924 hasConcept C207001950 @default.
• W2945668924 hasConcept C207583985 @default.
• W2945668924 hasConcept C2522874641 @default.
• W2945668924 hasConcept C2777546802 @default.
• W2945668924 hasConcept C2778042024 @default.
• W2945668924 hasConcept C2779134260 @default.
• W2945668924 hasConcept C2780942790 @default.
• W2945668924 hasConcept C3008058167 @default.
• W2945668924 hasConcept C524204448 @default.
• W2945668924 hasConcept C54355233 @default.
• W2945668924 hasConcept C71924100 @default.
• W2945668924 hasConcept C86803240 @default.
• W2945668924 hasConceptScore W2945668924C104317684 @default.
• W2945668924 hasConceptScore W2945668924C140704245 @default.
• W2945668924 hasConceptScore W2945668924C140933497 @default.
• W2945668924 hasConceptScore W2945668924C142724271 @default.
• W2945668924 hasConceptScore W2945668924C143065580 @default.
• W2945668924 hasConceptScore W2945668924C159047783 @default.
• W2945668924 hasConceptScore W2945668924C203014093 @default.
• W2945668924 hasConceptScore W2945668924C207001950 @default.
• W2945668924 hasConceptScore W2945668924C207583985 @default.
• W2945668924 hasConceptScore W2945668924C2522874641 @default.
• W2945668924 hasConceptScore W2945668924C2777546802 @default.
• W2945668924 hasConceptScore W2945668924C2778042024 @default.
• W2945668924 hasConceptScore W2945668924C2779134260 @default.
• W2945668924 hasConceptScore W2945668924C2780942790 @default.
• W2945668924 hasConceptScore W2945668924C3008058167 @default.
• W2945668924 hasConceptScore W2945668924C524204448 @default.
• W2945668924 hasConceptScore W2945668924C54355233 @default.
• W2945668924 hasConceptScore W2945668924C71924100 @default.
• W2945668924 hasConceptScore W2945668924C86803240 @default.
• W2945668924 hasIssue "7" @default.
• W2945668924 hasLocation W29456689241 @default.
• W2945668924 hasLocation W29456689242 @default.
• W2945668924 hasOpenAccess W2945668924 @default.
• W2945668924 hasPrimaryLocation W29456689241 @default.
• W2945668924 hasRelatedWork W2009671413 @default.
• W2945668924 hasRelatedWork W2036413119 @default.
• W2945668924 hasRelatedWork W2107663516 @default.
• W2945668924 hasRelatedWork W2130654686 @default.
• W2945668924 hasRelatedWork W2148114753 @default.

• next