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- W2945672034 abstract "The nuclear receptors REV-ERBα and -β link circadian rhythms and metabolism. Like other nuclear receptors, REV-ERB activity can be regulated by ligands, including naturally occurring heme. A putative ligand, SR9009, has been reported to elicit a range of beneficial effects in healthy as well as diseased animal models and cell systems. However, the direct involvement of REV-ERBs in these effects of SR9009 has not been thoroughly assessed, as experiments were not performed in the complete absence of both proteins. Here, we report the generation of a mouse model for conditional genetic deletion of REV-ERBα and -β. We show that SR9009 can decrease cell viability, rewire cellular metabolism, and alter gene transcription in hepatocytes and embryonic stem cells lacking both REV-ERBα and -β. Thus, the effects of SR9009 cannot be used solely as surrogate for REV-ERB activity." @default.
- W2945672034 created "2019-05-29" @default.
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- W2945672034 date "2019-05-24" @default.
- W2945672034 modified "2023-10-14" @default.
- W2945672034 title "SR9009 has REV-ERB–independent effects on cell proliferation and metabolism" @default.
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- W2945672034 doi "https://doi.org/10.1073/pnas.1904226116" @default.
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