FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945673755> ?p ?o ?g. }

• W2945673755 endingPage "e0217238" @default.
• W2945673755 startingPage "e0217238" @default.
• W2945673755 abstract "Objectives Vitamin D deficiency predicts unfavorable disease outcomes in inflammatory bowel disease. Endogenous vitamin D synthesis is affected by seasonal factors including sunlight exposure, raising the question whether seasonality determines the risk of vitamin D deficiency and may mask other clinical risk factors. Methods Univariable and multiple regression analyses were performed in a retrospective cohort of 384 patients to determine risk factors for vitamin D deficiency. Since the observed 25-hydroxyvitamin D [25(OH)D] concentrations followed a sinusoidal pattern over the year, all 25(OH)D concentrations were normalized for the predicted variability of the respective day of analysis based on a sinusoidal regression analysis of 25(OH)D test results obtained in more than 86,000 control serum samples. Results Vitamin D deficiency was highly prevalent in patients with Crohn’s disease or ulcerative colitis (63% and 55%, respectively) and associated with winter/spring seasons. After normalization of 25(OH)D concentrations for the day of analysis, vitamin D deficiency was associated with histories of complications related to inflammatory bowel disease, surgery, smoking and ongoing diarrhea while initial disease manifestation during adulthood, ongoing vitamin D supplementation and diagnosis of ulcerative colitis vs. Crohn’s disease appeared to be protective. Multiple regression analyses revealed that vitamin D deficiency was associated with disease activity in Crohn’s disease and anemia in ulcerative colitis patients. Only few deficient patients achieved sufficient 25(OH)D concentrations over time. However, increasing 25(OH)D concentrations correlated with improved Crohn’s disease activity. Conclusions Vitamin D deficiency was highly prevalent in patients with Crohn’s disease and ulcerative colitis and dependent on the season of the year. Following normalization for seasonality by sinusoidal regression analysis, vitamin D deficiency was found to be associated with parameters of complicated disease course while increasing 25(OH)D concentrations over time correlated with reduced activity of Crohn’s disease." @default.
• W2945673755 created "2019-05-29" @default.
• W2945673755 creator A5029086600 @default.
• W2945673755 creator A5038649106 @default.
• W2945673755 creator A5058384654 @default.
• W2945673755 creator A5085559293 @default.
• W2945673755 creator A5089845083 @default.
• W2945673755 date "2019-05-23" @default.
• W2945673755 modified "2023-10-10" @default.
• W2945673755 title "Seasonal variability of vitamin D status in patients with inflammatory bowel disease – A retrospective cohort study" @default.
• W2945673755 cites W1544124240 @default.
• W2945673755 cites W1963608958 @default.
• W2945673755 cites W1997900688 @default.
• W2945673755 cites W2013991824 @default.
• W2945673755 cites W2022661087 @default.
• W2945673755 cites W2032501249 @default.
• W2945673755 cites W2044384161 @default.
• W2945673755 cites W2060253882 @default.
• W2945673755 cites W2096936935 @default.
• W2945673755 cites W2108416075 @default.
• W2945673755 cites W2120166249 @default.
• W2945673755 cites W2153059487 @default.
• W2945673755 cites W2159920620 @default.
• W2945673755 cites W2293027646 @default.
• W2945673755 cites W2507447343 @default.
• W2945673755 cites W2562142629 @default.
• W2945673755 cites W2568629674 @default.
• W2945673755 cites W2574230683 @default.
• W2945673755 cites W2578117206 @default.
• W2945673755 cites W2617378763 @default.
• W2945673755 cites W2737961213 @default.
• W2945673755 cites W2746279552 @default.
• W2945673755 cites W2771203457 @default.
• W2945673755 cites W2788341997 @default.
• W2945673755 cites W2790470021 @default.
• W2945673755 cites W2794126809 @default.
• W2945673755 cites W2804074081 @default.
• W2945673755 cites W2907328358 @default.
• W2945673755 cites W2911066993 @default.
• W2945673755 cites W2942608313 @default.
• W2945673755 cites W4211241312 @default.
• W2945673755 cites W44195768 @default.
• W2945673755 cites W637887512 @default.
• W2945673755 doi "https://doi.org/10.1371/journal.pone.0217238" @default.
• W2945673755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6532907" @default.
• W2945673755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31120977" @default.
• W2945673755 hasPublicationYear "2019" @default.
• W2945673755 type Work @default.
• W2945673755 sameAs 2945673755 @default.
• W2945673755 citedByCount "10" @default.
• W2945673755 countsByYear W29456737552019 @default.
• W2945673755 countsByYear W29456737552020 @default.
• W2945673755 countsByYear W29456737552021 @default.
• W2945673755 countsByYear W29456737552022 @default.
• W2945673755 countsByYear W29456737552023 @default.
• W2945673755 crossrefType "journal-article" @default.
• W2945673755 hasAuthorship W2945673755A5029086600 @default.
• W2945673755 hasAuthorship W2945673755A5038649106 @default.
• W2945673755 hasAuthorship W2945673755A5058384654 @default.
• W2945673755 hasAuthorship W2945673755A5085559293 @default.
• W2945673755 hasAuthorship W2945673755A5089845083 @default.
• W2945673755 hasBestOaLocation W29456737551 @default.
• W2945673755 hasConcept C124490489 @default.
• W2945673755 hasConcept C126322002 @default.
• W2945673755 hasConcept C167135981 @default.
• W2945673755 hasConcept C2776940978 @default.
• W2945673755 hasConcept C2778260677 @default.
• W2945673755 hasConcept C2779134260 @default.
• W2945673755 hasConcept C2779280984 @default.
• W2945673755 hasConcept C2779740938 @default.
• W2945673755 hasConcept C2780479503 @default.
• W2945673755 hasConcept C71924100 @default.
• W2945673755 hasConcept C72563966 @default.
• W2945673755 hasConcept C90924648 @default.
• W2945673755 hasConceptScore W2945673755C124490489 @default.
• W2945673755 hasConceptScore W2945673755C126322002 @default.
• W2945673755 hasConceptScore W2945673755C167135981 @default.
• W2945673755 hasConceptScore W2945673755C2776940978 @default.
• W2945673755 hasConceptScore W2945673755C2778260677 @default.
• W2945673755 hasConceptScore W2945673755C2779134260 @default.
• W2945673755 hasConceptScore W2945673755C2779280984 @default.
• W2945673755 hasConceptScore W2945673755C2779740938 @default.
• W2945673755 hasConceptScore W2945673755C2780479503 @default.
• W2945673755 hasConceptScore W2945673755C71924100 @default.
• W2945673755 hasConceptScore W2945673755C72563966 @default.
• W2945673755 hasConceptScore W2945673755C90924648 @default.
• W2945673755 hasIssue "5" @default.
• W2945673755 hasLocation W29456737551 @default.
• W2945673755 hasLocation W29456737552 @default.
• W2945673755 hasLocation W29456737553 @default.
• W2945673755 hasLocation W29456737554 @default.
• W2945673755 hasLocation W29456737555 @default.
• W2945673755 hasLocation W29456737556 @default.
• W2945673755 hasOpenAccess W2945673755 @default.
• W2945673755 hasPrimaryLocation W29456737551 @default.
• W2945673755 hasRelatedWork W1819605542 @default.
• W2945673755 hasRelatedWork W2041633931 @default.
• W2945673755 hasRelatedWork W2083120593 @default.

• next