FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945677412> ?p ?o ?g. }

• W2945677412 abstract "Mastitis is a major problem for cows all over the world. For decades selection against mastitis has been performed through direct and indirect selection. Favorable outcomes of reduced mastitis incidence include: Economic gains, reduced use of antibiotics as well as improved animal welfare. Lately, new immunogenetic methods have emerged and the era of genomic selection has arrived. The innate and adaptive immune response, the bovine MHC and epigenetics are all of great relevance in this endeavor to improve immune response (IR) in cattle. Regarding breed differences in IR, few studies have been carried out on this subject and several factors need to be examined.The High Immune Response (HIR) technology is a patented method developed by the University of Guelph, it identifies so called high immune responders in the population. Another technique is Genome-wide association studies (GWAS), this method can be used to find the location of immune-related traits on the bovine genome. A few different GWAS will be accounted for. For example, GWAS searching for genome associations with natural antibodies (NAb) as well as for associations with antibody-mediated IR (AMIR) and cell-mediated IR (CMIR). Genomic selection (GS) is another modern technique in which estimated breeding values (EBV) are calculated based on single nucleotide polymorphisms (SNPs). This method requires a genotyped and phenotyped reference population and animals need only to be genotyped for the indicator markers to be assigned an EBV. This has reaped great success in increasing genetic gain as well as in decreasing generation intervals.Can these emerging methods surpass the results of the previously favored ones? The advantages as well as disadvantages are discussed. The disadvantages with the previous methods of selection for breeding are due to the time required and high expenses. Advantages with the emerging ones are faster results and shorter generation intervals. However, does the long-term genetic gain of GS actually surpass the traditional methods? Also, when manipulating the immune system, balance between responses must be considered. Otherwise, adverse effects like autoimmunity might appear. Sources of bias to the studies presented are also briefly mentioned. In conclusion, the area is still far too new to draw any major conclusions. However, it is a promising subject and further studies are of interest. The purpose of this literature study is to bring clarity to the question of whether it is possible to improve the bovine immune response to mastitis using immunogenetics." @default.
• W2945677412 created "2019-05-29" @default.
• W2945677412 creator A5046439529 @default.
• W2945677412 date "2019-04-24" @default.
• W2945677412 modified "2023-09-26" @default.
• W2945677412 title "Is it possible to improve thebovine immune response tomastitis using immunogenetics" @default.
• W2945677412 hasPublicationYear "2019" @default.
• W2945677412 type Work @default.
• W2945677412 sameAs 2945677412 @default.
• W2945677412 citedByCount "0" @default.
• W2945677412 crossrefType "journal-article" @default.
• W2945677412 hasAuthorship W2945677412A5046439529 @default.
• W2945677412 hasConcept C104317684 @default.
• W2945677412 hasConcept C106208931 @default.
• W2945677412 hasConcept C135763542 @default.
• W2945677412 hasConcept C153209595 @default.
• W2945677412 hasConcept C203014093 @default.
• W2945677412 hasConcept C2776344049 @default.
• W2945677412 hasConcept C2908647359 @default.
• W2945677412 hasConcept C54355233 @default.
• W2945677412 hasConcept C70721500 @default.
• W2945677412 hasConcept C71924100 @default.
• W2945677412 hasConcept C86803240 @default.
• W2945677412 hasConcept C8891405 @default.
• W2945677412 hasConcept C89423630 @default.
• W2945677412 hasConcept C99454951 @default.
• W2945677412 hasConceptScore W2945677412C104317684 @default.
• W2945677412 hasConceptScore W2945677412C106208931 @default.
• W2945677412 hasConceptScore W2945677412C135763542 @default.
• W2945677412 hasConceptScore W2945677412C153209595 @default.
• W2945677412 hasConceptScore W2945677412C203014093 @default.
• W2945677412 hasConceptScore W2945677412C2776344049 @default.
• W2945677412 hasConceptScore W2945677412C2908647359 @default.
• W2945677412 hasConceptScore W2945677412C54355233 @default.
• W2945677412 hasConceptScore W2945677412C70721500 @default.
• W2945677412 hasConceptScore W2945677412C71924100 @default.
• W2945677412 hasConceptScore W2945677412C86803240 @default.
• W2945677412 hasConceptScore W2945677412C8891405 @default.
• W2945677412 hasConceptScore W2945677412C89423630 @default.
• W2945677412 hasConceptScore W2945677412C99454951 @default.
• W2945677412 hasLocation W29456774121 @default.
• W2945677412 hasOpenAccess W2945677412 @default.
• W2945677412 hasPrimaryLocation W29456774121 @default.
• W2945677412 hasRelatedWork W1542104850 @default.
• W2945677412 hasRelatedWork W1568090966 @default.
• W2945677412 hasRelatedWork W1583760831 @default.
• W2945677412 hasRelatedWork W1893939741 @default.
• W2945677412 hasRelatedWork W1984241720 @default.
• W2945677412 hasRelatedWork W1997708663 @default.
• W2945677412 hasRelatedWork W2007795676 @default.
• W2945677412 hasRelatedWork W2008873439 @default.
• W2945677412 hasRelatedWork W2019024533 @default.
• W2945677412 hasRelatedWork W2113123047 @default.
• W2945677412 hasRelatedWork W2150779737 @default.
• W2945677412 hasRelatedWork W2150965754 @default.
• W2945677412 hasRelatedWork W2160570369 @default.
• W2945677412 hasRelatedWork W2187950292 @default.
• W2945677412 hasRelatedWork W2408813220 @default.
• W2945677412 hasRelatedWork W2437025187 @default.
• W2945677412 hasRelatedWork W2532124117 @default.
• W2945677412 hasRelatedWork W2805888979 @default.
• W2945677412 hasRelatedWork W2912798069 @default.
• W2945677412 hasRelatedWork W2985023021 @default.
• W2945677412 isParatext "false" @default.
• W2945677412 isRetracted "false" @default.
• W2945677412 magId "2945677412" @default.
• W2945677412 workType "article" @default.