FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945686154> ?p ?o ?g. }

• W2945686154 endingPage "8212" @default.
• W2945686154 startingPage "8207" @default.
• W2945686154 abstract "In this work, a combination of routine clinical practice and state-of-the-art laser ablation-inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOFMS) imaging is presented for multielement analysis of single cells on clinical samples. More specifically, routinely drawn blood thin films of a patient undergoing treatment with the anticancer drug cisplatin were studied. The presented label-free approach enabled rapid analysis of hundreds of cells at the single-cell level within a few minutes without additional tailored sample preparation. The employed low-dispersion LA setup is based on the tube-type COBALT ablation cell in combination with the aerosol rapid introduction system (ARIS) providing pixel-resolved imaging at 250–500 Hz for biological sample material. In order to cope with the short transient signals of only a few milliseconds delivered by the laser ablation setup, an icpTOF 2R TOF-based ICP-MS instrument was used for analysis, which has a mass coverage of m/z = 14–256. Leukocytes and erythrocytes, imaged with a laser beam of 4 μm and pixel interspacing of 2 μm, were differentiated on the basis of their intrinsic trace-elemental pattern. Overall, red blood cells displayed high iron intensities, whereas individual white blood cells were characterized by their high phosphorus content and increased sulfur signal. Unsupervised multivariate statistical analysis was applied to the data set. Principal component plots showed a clear clustering of leukocytes versus erythrocytes. The approach allowed studying not only the drug distribution between plasma and cells but also, for the first time, the preferential accumulation of platinum in different blood cell types without the need of cell fixation and labeling. Extracellular hotspots of platinum were observed, whereas only a small fraction of platinum was associated with erythrocytes. The investigation demonstrates the potential of low-dispersion LA-ICP-TOFMS as a rapid and powerful tool for label-free single-cell imaging in the clinical context." @default.
• W2945686154 created "2019-05-29" @default.
• W2945686154 creator A5007587804 @default.
• W2945686154 creator A5015090477 @default.
• W2945686154 creator A5017604548 @default.
• W2945686154 creator A5037329629 @default.
• W2945686154 creator A5071685694 @default.
• W2945686154 creator A5077074723 @default.
• W2945686154 creator A5079563405 @default.
• W2945686154 creator A5087632204 @default.
• W2945686154 date "2019-05-23" @default.
• W2945686154 modified "2023-10-18" @default.
• W2945686154 title "Laser Ablation-Inductively Coupled Plasma Time-of-Flight Mass Spectrometry Imaging of Trace Elements at the Single-Cell Level for Clinical Practice" @default.
• W2945686154 cites W1937753528 @default.
• W2945686154 cites W1969897569 @default.
• W2945686154 cites W1980501396 @default.
• W2945686154 cites W1996702397 @default.
• W2945686154 cites W2009827668 @default.
• W2945686154 cites W2046553238 @default.
• W2945686154 cites W2053129129 @default.
• W2945686154 cites W2075028690 @default.
• W2945686154 cites W2091820804 @default.
• W2945686154 cites W2102780371 @default.
• W2945686154 cites W2136671075 @default.
• W2945686154 cites W2141891750 @default.
• W2945686154 cites W2181374605 @default.
• W2945686154 cites W2239960579 @default.
• W2945686154 cites W2329072805 @default.
• W2945686154 cites W2411419231 @default.
• W2945686154 cites W2423375777 @default.
• W2945686154 cites W2533022942 @default.
• W2945686154 cites W2548467431 @default.
• W2945686154 cites W2569645528 @default.
• W2945686154 cites W2593629672 @default.
• W2945686154 cites W2765811273 @default.
• W2945686154 cites W2772035882 @default.
• W2945686154 cites W2778357085 @default.
• W2945686154 cites W2785070196 @default.
• W2945686154 cites W2885204924 @default.
• W2945686154 cites W2916468466 @default.
• W2945686154 doi "https://doi.org/10.1021/acs.analchem.9b00698" @default.
• W2945686154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31121096" @default.
• W2945686154 hasPublicationYear "2019" @default.
• W2945686154 type Work @default.
• W2945686154 sameAs 2945686154 @default.
• W2945686154 citedByCount "39" @default.
• W2945686154 countsByYear W29456861542019 @default.
• W2945686154 countsByYear W29456861542020 @default.
• W2945686154 countsByYear W29456861542021 @default.
• W2945686154 countsByYear W29456861542022 @default.
• W2945686154 countsByYear W29456861542023 @default.
• W2945686154 crossrefType "journal-article" @default.
• W2945686154 hasAuthorship W2945686154A5007587804 @default.
• W2945686154 hasAuthorship W2945686154A5015090477 @default.
• W2945686154 hasAuthorship W2945686154A5017604548 @default.
• W2945686154 hasAuthorship W2945686154A5037329629 @default.
• W2945686154 hasAuthorship W2945686154A5071685694 @default.
• W2945686154 hasAuthorship W2945686154A5077074723 @default.
• W2945686154 hasAuthorship W2945686154A5079563405 @default.
• W2945686154 hasAuthorship W2945686154A5087632204 @default.
• W2945686154 hasConcept C113196181 @default.
• W2945686154 hasConcept C120665830 @default.
• W2945686154 hasConcept C121332964 @default.
• W2945686154 hasConcept C127413603 @default.
• W2945686154 hasConcept C136229726 @default.
• W2945686154 hasConcept C146978453 @default.
• W2945686154 hasConcept C162356407 @default.
• W2945686154 hasConcept C165697059 @default.
• W2945686154 hasConcept C185592680 @default.
• W2945686154 hasConcept C2778902805 @default.
• W2945686154 hasConcept C2779188808 @default.
• W2945686154 hasConcept C43617362 @default.
• W2945686154 hasConcept C520434653 @default.
• W2945686154 hasConcept C71924100 @default.
• W2945686154 hasConceptScore W2945686154C113196181 @default.
• W2945686154 hasConceptScore W2945686154C120665830 @default.
• W2945686154 hasConceptScore W2945686154C121332964 @default.
• W2945686154 hasConceptScore W2945686154C127413603 @default.
• W2945686154 hasConceptScore W2945686154C136229726 @default.
• W2945686154 hasConceptScore W2945686154C146978453 @default.
• W2945686154 hasConceptScore W2945686154C162356407 @default.
• W2945686154 hasConceptScore W2945686154C165697059 @default.
• W2945686154 hasConceptScore W2945686154C185592680 @default.
• W2945686154 hasConceptScore W2945686154C2778902805 @default.
• W2945686154 hasConceptScore W2945686154C2779188808 @default.
• W2945686154 hasConceptScore W2945686154C43617362 @default.
• W2945686154 hasConceptScore W2945686154C520434653 @default.
• W2945686154 hasConceptScore W2945686154C71924100 @default.
• W2945686154 hasFunder F4320321730 @default.
• W2945686154 hasIssue "13" @default.
• W2945686154 hasLocation W29456861541 @default.
• W2945686154 hasLocation W29456861542 @default.
• W2945686154 hasOpenAccess W2945686154 @default.
• W2945686154 hasPrimaryLocation W29456861541 @default.
• W2945686154 hasRelatedWork W1940885666 @default.
• W2945686154 hasRelatedWork W1965319168 @default.
• W2945686154 hasRelatedWork W2052524705 @default.
• W2945686154 hasRelatedWork W2057758186 @default.

• next