FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945710132> ?p ?o ?g. }

• W2945710132 endingPage "698" @default.
• W2945710132 startingPage "692" @default.
• W2945710132 abstract "The treatment of nucleotide-binding domain and leucine-rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome-mediated pediatric inflammatory diseases is challenging. Here we studied whether cyclic adenosine monophosphate (cAMP) elevator forskolin could attenuate the nigericin-induced NLRP3-inflammasome activation and interleukin-1β (IL-1β) secretion in human macrophages. The proteins and messenger RNA (mRNA) levels of inflammasome structural proteins and proinflammatory cytokines were measured in forskolin-stimulated nigericin-activated human THP-1 macrophages and primary macrophages. Activation of THP-1 macrophages with nigericin increased the mRNA expression of NLRP3, IL-1β, and caspase-1 (P < 0.01). Forskolin stimulation had no effect on the mRNA expression of NLRP3, caspase-1, or IL-1β in nigericin-activated cells (P > 0.05), while their protein levels were significantly decreased (P < 0.05). Forskolin-mediated increase in cytoplasmic cAMP in non-activated cells was attenuated in nigericin-activated macrophages (P < 0.05). Basal IL-1β secretion increased from 584 to 2696 pg/mL (P < 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1β (P < 0.01). Forskolin also inhibited the IL-1β secretion from activated human primary macrophages. Forskolin inhibits the NLRP3 inflammasome activation and the secretion of mature IL-1β, in human macrophages. Forskolin and other cAMP elevator drugs could represent a novel approach for treatment of diseases associated with excessive inflammasome activation, like pediatric inflammatory diseases." @default.
• W2945710132 created "2019-05-29" @default.
• W2945710132 creator A5004566440 @default.
• W2945710132 creator A5018000360 @default.
• W2945710132 creator A5022423453 @default.
• W2945710132 creator A5026985930 @default.
• W2945710132 creator A5055245284 @default.
• W2945710132 creator A5058020478 @default.
• W2945710132 creator A5059505265 @default.
• W2945710132 creator A5089415929 @default.
• W2945710132 date "2019-05-13" @default.
• W2945710132 modified "2023-10-18" @default.
• W2945710132 title "Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages" @default.
• W2945710132 cites W1561041814 @default.
• W2945710132 cites W1680053970 @default.
• W2945710132 cites W1764212712 @default.
• W2945710132 cites W1964535559 @default.
• W2945710132 cites W1980093972 @default.
• W2945710132 cites W2005410446 @default.
• W2945710132 cites W2025974845 @default.
• W2945710132 cites W2058645677 @default.
• W2945710132 cites W2068633454 @default.
• W2945710132 cites W2077207983 @default.
• W2945710132 cites W2084158898 @default.
• W2945710132 cites W2118403357 @default.
• W2945710132 cites W2118918019 @default.
• W2945710132 cites W2135908108 @default.
• W2945710132 cites W2360882154 @default.
• W2945710132 cites W2516960518 @default.
• W2945710132 cites W2596815715 @default.
• W2945710132 cites W2910104850 @default.
• W2945710132 cites W2911973711 @default.
• W2945710132 cites W2947089396 @default.
• W2945710132 doi "https://doi.org/10.1038/s41390-019-0418-4" @default.
• W2945710132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31086288" @default.
• W2945710132 hasPublicationYear "2019" @default.
• W2945710132 type Work @default.
• W2945710132 sameAs 2945710132 @default.
• W2945710132 citedByCount "14" @default.
• W2945710132 countsByYear W29457101322019 @default.
• W2945710132 countsByYear W29457101322020 @default.
• W2945710132 countsByYear W29457101322021 @default.
• W2945710132 countsByYear W29457101322022 @default.
• W2945710132 countsByYear W29457101322023 @default.
• W2945710132 crossrefType "journal-article" @default.
• W2945710132 hasAuthorship W2945710132A5004566440 @default.
• W2945710132 hasAuthorship W2945710132A5018000360 @default.
• W2945710132 hasAuthorship W2945710132A5022423453 @default.
• W2945710132 hasAuthorship W2945710132A5026985930 @default.
• W2945710132 hasAuthorship W2945710132A5055245284 @default.
• W2945710132 hasAuthorship W2945710132A5058020478 @default.
• W2945710132 hasAuthorship W2945710132A5059505265 @default.
• W2945710132 hasAuthorship W2945710132A5089415929 @default.
• W2945710132 hasBestOaLocation W29457101321 @default.
• W2945710132 hasConcept C126322002 @default.
• W2945710132 hasConcept C134018914 @default.
• W2945710132 hasConcept C139964883 @default.
• W2945710132 hasConcept C164027704 @default.
• W2945710132 hasConcept C170493617 @default.
• W2945710132 hasConcept C185592680 @default.
• W2945710132 hasConcept C187831198 @default.
• W2945710132 hasConcept C24998067 @default.
• W2945710132 hasConcept C2776914184 @default.
• W2945710132 hasConcept C2777209026 @default.
• W2945710132 hasConcept C2777330628 @default.
• W2945710132 hasConcept C2779276759 @default.
• W2945710132 hasConcept C41625074 @default.
• W2945710132 hasConcept C49039625 @default.
• W2945710132 hasConcept C55493867 @default.
• W2945710132 hasConcept C71924100 @default.
• W2945710132 hasConcept C86803240 @default.
• W2945710132 hasConcept C95444343 @default.
• W2945710132 hasConceptScore W2945710132C126322002 @default.
• W2945710132 hasConceptScore W2945710132C134018914 @default.
• W2945710132 hasConceptScore W2945710132C139964883 @default.
• W2945710132 hasConceptScore W2945710132C164027704 @default.
• W2945710132 hasConceptScore W2945710132C170493617 @default.
• W2945710132 hasConceptScore W2945710132C185592680 @default.
• W2945710132 hasConceptScore W2945710132C187831198 @default.
• W2945710132 hasConceptScore W2945710132C24998067 @default.
• W2945710132 hasConceptScore W2945710132C2776914184 @default.
• W2945710132 hasConceptScore W2945710132C2777209026 @default.
• W2945710132 hasConceptScore W2945710132C2777330628 @default.
• W2945710132 hasConceptScore W2945710132C2779276759 @default.
• W2945710132 hasConceptScore W2945710132C41625074 @default.
• W2945710132 hasConceptScore W2945710132C49039625 @default.
• W2945710132 hasConceptScore W2945710132C55493867 @default.
• W2945710132 hasConceptScore W2945710132C71924100 @default.
• W2945710132 hasConceptScore W2945710132C86803240 @default.
• W2945710132 hasConceptScore W2945710132C95444343 @default.
• W2945710132 hasIssue "6" @default.
• W2945710132 hasLocation W29457101321 @default.
• W2945710132 hasLocation W29457101322 @default.
• W2945710132 hasLocation W29457101323 @default.
• W2945710132 hasOpenAccess W2945710132 @default.
• W2945710132 hasPrimaryLocation W29457101321 @default.
• W2945710132 hasRelatedWork W1861790843 @default.
• W2945710132 hasRelatedWork W2007506634 @default.

• next