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- W2945723977 abstract "Abstract Baclofen, a selective GABAB-receptor agonist, is extensively used as a myorelaxant drug or, at high doses, to maintain ethanol abstinence in chronic alcoholics, despite the lack of high-level evidence of effectiveness. At therapeutic doses, neurological adverse effects, including sedation, are relatively frequent, but usually disappear due to the development of tolerance during prolonged treatment. Withdrawal syndrome has been reported after the cessation of repeated baclofen treatments. In overdose, neurotoxicity may be life-threatening including consciousness impairment, respiratory depression, and characteristic electroencephalography burst-suppression and isoelectrical patterns. Management is supportive including tracheal intubation and mechanical ventilation. No antidote is available. Although high-dose baclofen can be used with manageable side effects, dose-dependent risk of hospitalization and death have been reported when compared to other psychotropic drugs and approved medications used to treat ethanol dependence." @default.
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- W2945723977 date "2019-01-01" @default.
- W2945723977 modified "2023-10-14" @default.
- W2945723977 title "Baclofen-Induced Neurotoxicity" @default.
- W2945723977 doi "https://doi.org/10.1016/b978-0-12-813125-1.00065-9" @default.
- W2945723977 hasPublicationYear "2019" @default.
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