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• W2945730423 abstract "Protein ubiquitination is an essential cellular process that maintains protein homeostasis, regulates protein, and cell functions, and removes aggregated and misfolded protein. Disruption in function of any of the protein components of the ubiquitination pathway is associated with human diseases including cancers. An important member in the ubiquitination cascade is the very large E3 ligase family that directs substrate modification. The RING-type E3 ligases possess a cysteine/histidine-rich zinc-binding RING domain that confers ligase functionality. RING domains adopt a canonical ββα-fold. TRIM proteins represent a novel class of RING-type E3 ligase. TRIM proteins consist of an N-terminal RING domain followed by one or two B-box domains. The two types of B-box domains play essential roles in protein ubiquitination by contributing to substrate targeting, ligase activity enhancement, and redundancy of ligase activity. This review presents a general background of the B-box domains, a structural and functional comparison with RING domains, and a summary of recent work demonstrating their role in proteolysis. We discuss new findings that reveal B-box domains which are ubiquitous and are found in non-TRIM plant proteins without the adjacent RING domain, indicating that B-boxes are members of RING-class E3 ligases." @default.
• W2945730423 created "2019-05-29" @default.
• W2945730423 creator A5076930509 @default.
• W2945730423 date "2019-06-19" @default.
• W2945730423 modified "2023-10-14" @default.
• W2945730423 title "Zinc-Binding B-Box Domains with RING Folds Serve Critical Roles in the Protein Ubiquitination Pathways in Plants and Animals" @default.
• W2945730423 cites W1497941038 @default.
• W2945730423 cites W1504515318 @default.
• W2945730423 cites W1531234455 @default.
• W2945730423 cites W1540713407 @default.
• W2945730423 cites W1576464279 @default.
• W2945730423 cites W1598704961 @default.
• W2945730423 cites W1832030339 @default.
• W2945730423 cites W1892570697 @default.
• W2945730423 cites W1902704112 @default.
• W2945730423 cites W1928629620 @default.
• W2945730423 cites W1964504843 @default.
• W2945730423 cites W1964794539 @default.
• W2945730423 cites W1968157723 @default.
• W2945730423 cites W1970853667 @default.
• W2945730423 cites W1971700349 @default.
• W2945730423 cites W1972514324 @default.
• W2945730423 cites W1972592088 @default.
• W2945730423 cites W1973921769 @default.
• W2945730423 cites W1974923921 @default.
• W2945730423 cites W1976617857 @default.
• W2945730423 cites W1977491708 @default.
• W2945730423 cites W1979019144 @default.
• W2945730423 cites W1980429090 @default.
• W2945730423 cites W1982004004 @default.
• W2945730423 cites W1985225337 @default.
• W2945730423 cites W1985435115 @default.
• W2945730423 cites W1985891703 @default.
• W2945730423 cites W1986335988 @default.
• W2945730423 cites W1988617344 @default.
• W2945730423 cites W1989480480 @default.
• W2945730423 cites W1990643576 @default.
• W2945730423 cites W1992060900 @default.
• W2945730423 cites W1997318570 @default.
• W2945730423 cites W1997538265 @default.
• W2945730423 cites W1998662277 @default.
• W2945730423 cites W1999793253 @default.
• W2945730423 cites W2000146105 @default.
• W2945730423 cites W2002569752 @default.
• W2945730423 cites W2003002450 @default.
• W2945730423 cites W2003090403 @default.
• W2945730423 cites W2005670638 @default.
• W2945730423 cites W2009154598 @default.
• W2945730423 cites W2009614729 @default.
• W2945730423 cites W2010369105 @default.
• W2945730423 cites W2012688036 @default.
• W2945730423 cites W2013497239 @default.
• W2945730423 cites W2014344891 @default.
• W2945730423 cites W2019500431 @default.
• W2945730423 cites W2020847285 @default.
• W2945730423 cites W2020909982 @default.
• W2945730423 cites W2028287055 @default.
• W2945730423 cites W2029836735 @default.
• W2945730423 cites W2031490422 @default.
• W2945730423 cites W2034203606 @default.
• W2945730423 cites W2035046825 @default.
• W2945730423 cites W2037454778 @default.
• W2945730423 cites W2038638713 @default.
• W2945730423 cites W2039931633 @default.
• W2945730423 cites W2041194506 @default.
• W2945730423 cites W2041517382 @default.
• W2945730423 cites W2045128403 @default.
• W2945730423 cites W2045528596 @default.
• W2945730423 cites W2046135777 @default.
• W2945730423 cites W2047063821 @default.
• W2945730423 cites W2047147330 @default.
• W2945730423 cites W2047368106 @default.
• W2945730423 cites W2050465152 @default.
• W2945730423 cites W2051520229 @default.
• W2945730423 cites W2055019434 @default.
• W2945730423 cites W2055458365 @default.
• W2945730423 cites W2059091401 @default.
• W2945730423 cites W2060098193 @default.
• W2945730423 cites W2062155998 @default.
• W2945730423 cites W2063690467 @default.
• W2945730423 cites W2065633276 @default.
• W2945730423 cites W2067127659 @default.
• W2945730423 cites W2067706259 @default.
• W2945730423 cites W2072583138 @default.
• W2945730423 cites W2073618740 @default.
• W2945730423 cites W2078954800 @default.
• W2945730423 cites W2079266876 @default.
• W2945730423 cites W2081338850 @default.
• W2945730423 cites W2083017377 @default.
• W2945730423 cites W2086717365 @default.
• W2945730423 cites W2087293747 @default.
• W2945730423 cites W2088854979 @default.
• W2945730423 cites W2089668045 @default.
• W2945730423 cites W2092698212 @default.
• W2945730423 cites W2095544923 @default.
• W2945730423 cites W2103395151 @default.
• W2945730423 cites W2105006635 @default.
• W2945730423 cites W2106382070 @default.
• W2945730423 cites W2110609746 @default.
• W2945730423 cites W2112848547 @default.

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