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• W2945740624 abstract "Abstract Context Patients with rheumatoid arthritis have a higher cardiovascular risk due to the prevalence of cardiovascular risk factors and metabolic alterations derived from the inflammatory activity and the treatment of their disease. A systematic evaluation of the effect of statins on lipid fractions and cardiovascular outcomes has not been carried out specifically in patients with rheumatoid arthritis. Methods A literature search was conducted in Medline (PubMed), Embase, Lilacs, Scielo, and Cochrane. Randomized and non-randomized clinical trials were selected that evaluated the impact of statins on mortality, cardiovascular events, lipid fractions and disease activity in patients with rheumatoid arthritis. A paired evaluation of risk of bias was carried out, along with a meta-analysis using RevMan 5.3®. Results A total of 5 studies and 383 patients were included in the analysis. The use of statins among patients with rheumatoid arthritis significantly reduced total cholesterol levels: −46.16 mg/dL (95% CI: [−53.89, −38.46]; I2: 86%), LDLc: −18.13 mg/dL (95% CI: [−21.8, −14.4], I2: 97%) and TG of −34.95 mg/dL (95% CI: [−44.3, −25.6], I2: 0%), without significant changes in HDLc. It also reduced the activity of the disease (DAS28) by 0.73 (95% CI: [−0.94, −0.53], I2: 96%). No study was found that reported mortality or cardiovascular outcomes. Conclusion The lipid-lowering effect of statins in patients with rheumatoid arthritis is consistent with that found in other populations. There is a slight impact in reducing the activity of the disease, but reducing the risk of cardiovascular events in this specific population has not been studied." @default.
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• W2945740624 date "2019-01-01" @default.
• W2945740624 modified "2023-10-18" @default.
• W2945740624 title "Therapeutic impact of statins on the lipid profile and cardiovascular risk of patients with rheumatoid arthritis: Systematic literature review and meta-analysis" @default.
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• W2945740624 doi "https://doi.org/10.1016/j.rcreue.2018.10.004" @default.
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