Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945757124> ?p ?o ?g. }
- W2945757124 endingPage "1655" @default.
- W2945757124 startingPage "1645" @default.
- W2945757124 abstract "Corchorusoside C (1), isolated from Streptocaulon juventas collected in Vietnam, was found to be nontoxic in a zebrafish (Danio rerio) model and to induce cytotoxicity in several cancer cell lines with notable selective activity against prostate DU-145 cancer cells (IC50 0.08 μM). Moreover, corchorusoside C induced DU-145 cell shrinkage and cell detachment. In CCD-112CoN colon normal cells, 1 showed significantly reduced cytotoxic activity (IC50 2.3 μM). A preliminary mechanistic study indicated that 1 inhibits activity and protein expression of NF-κB (p50 and p65), IKK (α and β), and ICAM-1 in DU-145 cells. ROS concentrations increased at 5 h post-treatment, and MTP decreased in a dose-dependent manner. Moreover, decreased protein expression of Bcl-2 and increased expression of PARP-1 was observed. Furthermore, corchorusoside C increased both the activity and protein levels of caspases 3 and 7. Additionally, 1 induced sub-G1 population increase of DU-145 cells and modulated caspases in zebrafish with nondifferential morphological effects. Therefore, corchorusoside C (1) induces apoptosis in DU-145 cells and targets the same pathways both in vitro and in vivo in zebrafish. Thus, the use of zebrafish assays seems worthy of wider application than is currently employed for the evaluation of potential anticancer agents of natural origin." @default.
- W2945757124 created "2019-05-29" @default.
- W2945757124 creator A5000137077 @default.
- W2945757124 creator A5012601956 @default.
- W2945757124 creator A5013002429 @default.
- W2945757124 creator A5014354717 @default.
- W2945757124 creator A5016596110 @default.
- W2945757124 creator A5046341218 @default.
- W2945757124 creator A5046786261 @default.
- W2945757124 creator A5071949874 @default.
- W2945757124 creator A5076041060 @default.
- W2945757124 date "2019-05-23" @default.
- W2945757124 modified "2023-09-27" @default.
- W2945757124 title "Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from <i>Streptocaulon juventas</i>" @default.
- W2945757124 cites W181281151 @default.
- W2945757124 cites W1822745879 @default.
- W2945757124 cites W1969423849 @default.
- W2945757124 cites W1990484548 @default.
- W2945757124 cites W2008757142 @default.
- W2945757124 cites W2012868121 @default.
- W2945757124 cites W2013433134 @default.
- W2945757124 cites W2020670611 @default.
- W2945757124 cites W2021819934 @default.
- W2945757124 cites W2025312106 @default.
- W2945757124 cites W2026723151 @default.
- W2945757124 cites W2027829078 @default.
- W2945757124 cites W2034335846 @default.
- W2945757124 cites W2041163647 @default.
- W2945757124 cites W2046940173 @default.
- W2945757124 cites W2052106507 @default.
- W2945757124 cites W2055878807 @default.
- W2945757124 cites W2070113304 @default.
- W2945757124 cites W2070358111 @default.
- W2945757124 cites W2076132542 @default.
- W2945757124 cites W2081787890 @default.
- W2945757124 cites W2091114312 @default.
- W2945757124 cites W2092275781 @default.
- W2945757124 cites W2105469514 @default.
- W2945757124 cites W2114434155 @default.
- W2945757124 cites W2115290743 @default.
- W2945757124 cites W2134887638 @default.
- W2945757124 cites W2136628003 @default.
- W2945757124 cites W2137330819 @default.
- W2945757124 cites W2144578753 @default.
- W2945757124 cites W2145028653 @default.
- W2945757124 cites W2148125367 @default.
- W2945757124 cites W2152793164 @default.
- W2945757124 cites W2284744667 @default.
- W2945757124 cites W2319985701 @default.
- W2945757124 cites W2339226255 @default.
- W2945757124 cites W2469033733 @default.
- W2945757124 cites W2513424134 @default.
- W2945757124 cites W2519786994 @default.
- W2945757124 cites W2591062156 @default.
- W2945757124 cites W2744199249 @default.
- W2945757124 cites W2766197806 @default.
- W2945757124 cites W2769631482 @default.
- W2945757124 cites W2773689458 @default.
- W2945757124 cites W2781525129 @default.
- W2945757124 cites W2896950844 @default.
- W2945757124 cites W2907787870 @default.
- W2945757124 cites W3141110625 @default.
- W2945757124 cites W4255929444 @default.
- W2945757124 doi "https://doi.org/10.1021/acs.jnatprod.9b00140" @default.
- W2945757124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6615048" @default.
- W2945757124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31120251" @default.
- W2945757124 hasPublicationYear "2019" @default.
- W2945757124 type Work @default.
- W2945757124 sameAs 2945757124 @default.
- W2945757124 citedByCount "14" @default.
- W2945757124 countsByYear W29457571242020 @default.
- W2945757124 countsByYear W29457571242021 @default.
- W2945757124 countsByYear W29457571242022 @default.
- W2945757124 countsByYear W29457571242023 @default.
- W2945757124 crossrefType "journal-article" @default.
- W2945757124 hasAuthorship W2945757124A5000137077 @default.
- W2945757124 hasAuthorship W2945757124A5012601956 @default.
- W2945757124 hasAuthorship W2945757124A5013002429 @default.
- W2945757124 hasAuthorship W2945757124A5014354717 @default.
- W2945757124 hasAuthorship W2945757124A5016596110 @default.
- W2945757124 hasAuthorship W2945757124A5046341218 @default.
- W2945757124 hasAuthorship W2945757124A5046786261 @default.
- W2945757124 hasAuthorship W2945757124A5071949874 @default.
- W2945757124 hasAuthorship W2945757124A5076041060 @default.
- W2945757124 hasBestOaLocation W29457571242 @default.
- W2945757124 hasConcept C104317684 @default.
- W2945757124 hasConcept C109316439 @default.
- W2945757124 hasConcept C121608353 @default.
- W2945757124 hasConcept C12519072 @default.
- W2945757124 hasConcept C1491633281 @default.
- W2945757124 hasConcept C153911025 @default.
- W2945757124 hasConcept C154317977 @default.
- W2945757124 hasConcept C185592680 @default.
- W2945757124 hasConcept C190283241 @default.
- W2945757124 hasConcept C202751555 @default.
- W2945757124 hasConcept C207001950 @default.
- W2945757124 hasConcept C2776878037 @default.
- W2945757124 hasConcept C2780384893 @default.