Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945762406> ?p ?o ?g. }
- W2945762406 startingPage "651745" @default.
- W2945762406 abstract "Abstract The proportion and distribution of local inhibitory neurons (interneurons) in the thalamus varies widely across mammals. This is reflected in the structure of thalamic local circuits, which is more complex in primates compared to smaller-brained mammals like rodents. An increase in the number of thalamic interneurons could arise from addition of novel interneuron types or from elaboration of a plesiomorphic ontogenetic program, common to all mammals. The former has been proposed for the human brain, with migration of interneurons from the ventral telencephalon into higher order thalamus as one of its unique features (Letinic and Rakic, 2001). Here, we identify a larger than expected complexity and distribution of interneurons across the mouse thalamus. All thalamic interneurons can be traced back to two developmental programs: one specified in the midbrain and the other in the forebrain. Interneurons migrate to functionally distinct thalamic nuclei, where the midbrain-derived cells populate the sensory thalamus, and forebrain-generated interneurons only the higher order regions. The latter interneuron type may be homologous to the one previously considered to be human-specific, while we also observe that markers for the midbrain-born class are abundantly expressed in the primate thalamus. These data therefore point to a shared ontogenetic organization of thalamic interneurons across mammals." @default.
- W2945762406 created "2019-05-29" @default.
- W2945762406 creator A5013522200 @default.
- W2945762406 creator A5029264892 @default.
- W2945762406 creator A5035329231 @default.
- W2945762406 creator A5043155892 @default.
- W2945762406 creator A5065714522 @default.
- W2945762406 creator A5068795703 @default.
- W2945762406 date "2019-05-28" @default.
- W2945762406 modified "2023-09-23" @default.
- W2945762406 title "Inhibitory interneurons distribute widely across the mouse thalamus and form ontogenetic spatial clusters" @default.
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