FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945768275> ?p ?o ?g. }

• W2945768275 endingPage "712" @default.
• W2945768275 startingPage "712" @default.
• W2945768275 abstract "Aerobic glycolysis is one of the important metabolic characteristics of many malignant tumors. Pyruvate dehydrogenase kinase (PDHK) plays a key role in aerobic glycolysis by phosphorylating the E1α subunit of pyruvate dehydrogenase (PDH). Hence, PDHK has been recognized as a molecular target for cancer treatment. Here, we report that huzhangoside A (Hu.A), a triterpenoid glycoside compound isolated from several plants of the Anemone genus, acts as a novel PDHK inhibitor. Hu.A was found to decrease the cell viability of human breast cancer MDA-MB-231, hepatocellular carcinoma Hep3B, colon cancer HT-29, DLD-1, and murine lewis lung carcinoma LLC cell lines. The activity of PDHK1 was decreased by Hu.A in both in vitro assays and in vivo assays in DLD-1 cells. Hu.A significantly increased the oxygen consumption and decreased the secretory lactate levels in DLD-1 cells. In addition, Hu.A interacted with the ATP-binding pocket of PDHK1 without affecting the interaction of PDHK1 and pyruvate dehydrogenase complex (PDC) subunits. Furthermore, Hu.A significantly induced mitochondrial reactive oxygen species (ROS) and depolarized the mitochondrial membrane potential in DLD-1 cells. Consistently, when Hu.A was intraperitoneally injected into LLC allograft mice, the tumor growth was significantly decreased. In conclusion, Hu.A suppressed the growth of tumors in both in vitro and in vivo models via inhibition of PDHK activity." @default.
• W2945768275 created "2019-05-29" @default.
• W2945768275 creator A5021043061 @default.
• W2945768275 creator A5024364515 @default.
• W2945768275 creator A5041269113 @default.
• W2945768275 creator A5053329823 @default.
• W2945768275 creator A5058725113 @default.
• W2945768275 creator A5066705825 @default.
• W2945768275 creator A5070010238 @default.
• W2945768275 creator A5072574087 @default.
• W2945768275 creator A5074483970 @default.
• W2945768275 creator A5077539926 @default.
• W2945768275 creator A5082614396 @default.
• W2945768275 date "2019-05-23" @default.
• W2945768275 modified "2023-10-05" @default.
• W2945768275 title "Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity" @default.
• W2945768275 cites W1489146268 @default.
• W2945768275 cites W1644803659 @default.
• W2945768275 cites W1703016739 @default.
• W2945768275 cites W1865337518 @default.
• W2945768275 cites W1949250268 @default.
• W2945768275 cites W1976460633 @default.
• W2945768275 cites W1980438140 @default.
• W2945768275 cites W1981233558 @default.
• W2945768275 cites W1983824186 @default.
• W2945768275 cites W2000697370 @default.
• W2945768275 cites W2001958358 @default.
• W2945768275 cites W2005833897 @default.
• W2945768275 cites W2007303140 @default.
• W2945768275 cites W2014791035 @default.
• W2945768275 cites W2022392803 @default.
• W2945768275 cites W2027705428 @default.
• W2945768275 cites W2033958147 @default.
• W2945768275 cites W2074171009 @default.
• W2945768275 cites W2083539959 @default.
• W2945768275 cites W2087488172 @default.
• W2945768275 cites W2088210835 @default.
• W2945768275 cites W2097259163 @default.
• W2945768275 cites W2100723895 @default.
• W2945768275 cites W2101075480 @default.
• W2945768275 cites W2151260260 @default.
• W2945768275 cites W2158506244 @default.
• W2945768275 cites W2170096200 @default.
• W2945768275 cites W2290399183 @default.
• W2945768275 cites W2345381093 @default.
• W2945768275 cites W2602189337 @default.
• W2945768275 cites W2687045820 @default.
• W2945768275 cites W4233270123 @default.
• W2945768275 doi "https://doi.org/10.3390/cancers11050712" @default.
• W2945768275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6562422" @default.
• W2945768275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31126094" @default.
• W2945768275 hasPublicationYear "2019" @default.
• W2945768275 type Work @default.
• W2945768275 sameAs 2945768275 @default.
• W2945768275 citedByCount "15" @default.
• W2945768275 countsByYear W29457682752020 @default.
• W2945768275 countsByYear W29457682752021 @default.
• W2945768275 countsByYear W29457682752022 @default.
• W2945768275 countsByYear W29457682752023 @default.
• W2945768275 crossrefType "journal-article" @default.
• W2945768275 hasAuthorship W2945768275A5021043061 @default.
• W2945768275 hasAuthorship W2945768275A5024364515 @default.
• W2945768275 hasAuthorship W2945768275A5041269113 @default.
• W2945768275 hasAuthorship W2945768275A5053329823 @default.
• W2945768275 hasAuthorship W2945768275A5058725113 @default.
• W2945768275 hasAuthorship W2945768275A5066705825 @default.
• W2945768275 hasAuthorship W2945768275A5070010238 @default.
• W2945768275 hasAuthorship W2945768275A5072574087 @default.
• W2945768275 hasAuthorship W2945768275A5074483970 @default.
• W2945768275 hasAuthorship W2945768275A5077539926 @default.
• W2945768275 hasAuthorship W2945768275A5082614396 @default.
• W2945768275 hasBestOaLocation W29457682751 @default.
• W2945768275 hasConcept C121608353 @default.
• W2945768275 hasConcept C150903083 @default.
• W2945768275 hasConcept C181199279 @default.
• W2945768275 hasConcept C185592680 @default.
• W2945768275 hasConcept C190098323 @default.
• W2945768275 hasConcept C20251656 @default.
• W2945768275 hasConcept C202751555 @default.
• W2945768275 hasConcept C207001950 @default.
• W2945768275 hasConcept C2777318727 @default.
• W2945768275 hasConcept C2779707156 @default.
• W2945768275 hasConcept C2780854706 @default.
• W2945768275 hasConcept C2910680157 @default.
• W2945768275 hasConcept C48349386 @default.
• W2945768275 hasConcept C502942594 @default.
• W2945768275 hasConcept C54355233 @default.
• W2945768275 hasConcept C55493867 @default.
• W2945768275 hasConcept C55885012 @default.
• W2945768275 hasConcept C62112901 @default.
• W2945768275 hasConcept C62231903 @default.
• W2945768275 hasConcept C86803240 @default.
• W2945768275 hasConcept C88099638 @default.
• W2945768275 hasConcept C9506865 @default.
• W2945768275 hasConcept C96232424 @default.
• W2945768275 hasConceptScore W2945768275C121608353 @default.
• W2945768275 hasConceptScore W2945768275C150903083 @default.
• W2945768275 hasConceptScore W2945768275C181199279 @default.

• next