Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945774729> ?p ?o ?g. }
- W2945774729 abstract "Summary Aberrant macrophage activation during intracellular infection generates important immunopathologies that can cause severe human morbidity. A better understanding of microbial immune subversion strategies and macrophage phenotypic and functional responses is a prerequisite for the design of novel, host-directed intervention strategies. Here, we uncover a fine-tuned transcriptional response induced in primary macrophages infected by the human parasite Leishmania amazonensis that prevents NF-κB and NLRP3 inflammasome activation. This unusual subversion is characterized by respectively suppression and induction of activating and de-activating components of the NF-κB and NLRP3 pathways. This dichotomic modulation was associated with histone H3 hypoacetylation at promoters of NF-κB-related, pro-inflammatory genes. Our results reveal a novel Leishmania immune subversion strategy targeting host cell epigenetic regulation to modulate the macrophage phenotype. Modulation of the macrophage epigenetic landscape establishes conditions beneficial for intracellular parasite survival, and opens interesting new venues for host-directed, anti-microbial drug discovery." @default.
- W2945774729 created "2019-05-29" @default.
- W2945774729 creator A5006612133 @default.
- W2945774729 creator A5010811924 @default.
- W2945774729 creator A5019274543 @default.
- W2945774729 creator A5019495448 @default.
- W2945774729 creator A5027073669 @default.
- W2945774729 creator A5034773695 @default.
- W2945774729 creator A5040926327 @default.
- W2945774729 creator A5044922581 @default.
- W2945774729 creator A5045778354 @default.
- W2945774729 creator A5049995131 @default.
- W2945774729 creator A5049997723 @default.
- W2945774729 creator A5082833494 @default.
- W2945774729 date "2019-05-24" @default.
- W2945774729 modified "2023-09-26" @default.
- W2945774729 title "Leishmania targets the macrophage epigenome and dampens the NF-κB/NLRP3-mediated inflammatory response" @default.
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