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- W2945777622 abstract "Five new diterpenes, including an unprecedented 5,5,6,6,5-pentacyclic diterpene, sponalactone (1), two new spongian diterpenes, 17- O-acetylepispongiatriol (2) and 17- O-acetylspongiatriol (3), and two new spongian diterpene artifacts, 15α,16α-dimethoxy-15,16-dihydroepispongiatriol (4) and 15α-ethoxyepispongiatriol-16(15 H)-one (5), were isolated from a South China Sea collection of the marine sponge Spongia officinalis, together with three known analogues (6-8). The structures of the new diterpenes were elucidated by extensive spectroscopic analysis. The absolute configurations were established on the basis of ECD data. Compounds 1-5 and 7 exhibited moderate inhibition against LPS-induced NO production in RAW264.7 macrophages with IC50 values of 12-32 μM." @default.
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- W2945777622 date "2019-05-16" @default.
- W2945777622 modified "2023-09-27" @default.
- W2945777622 title "Spongian Diterpenes Including One with a Rearranged Skeleton from the Marine Sponge <i>Spongia officinalis</i>" @default.
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- W2945777622 doi "https://doi.org/10.1021/acs.jnatprod.9b00270" @default.
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