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• W2945806954 abstract "Abstract Metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis is a hallmark of osteosarcoma (OS). However, the mechanisms of the metabolic switch have not been completely elucidated. Here we reported that the miR-23b-3p was significantly upregulated in OS cells. Functional studies suggested that knockdown of miR-23b-3p could inhibit OS cell proliferation in vitro or in vivo. In addition, suppression of miR-23b-3p could lead to upregulation of OXPHOS and suppression of glycolysis. Mechanistically, miR-23b-3p promoted OS cell proliferation and inhibited OXPHOS in OS, at least in part, by directly targeting peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1α) and inhibiting its expression. Our data highlights important roles of miR-23b-3p and PGC1α in glucose metabolism reprogram of OS. The suppression of miR-23b-3p may provide effective therapeutic strategies for the treatment of OS." @default.
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• W2945806954 date "2019-05-16" @default.
• W2945806954 modified "2023-10-10" @default.
• W2945806954 title "miR-23b-3p suppressing PGC1α promotes proliferation through reprogramming metabolism in osteosarcoma" @default.
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• W2945806954 doi "https://doi.org/10.1038/s41419-019-1614-1" @default.
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