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• W2945809301 abstract "Bone volumes and quality are related to their hormone levels in laying hens. In this study, we investigated letrozole (LZ) induced effects on the physicochemical properties of cortical bone in laying hens. After 9-wk LZ treatment, we observed that LZ could decrease estrogen level in laying hens. As a result, both the plasma tartrate-resistant acid phosphatase and bone Gla protein activities were suppressed significantly. In addition, carbonate substitution was inhibited significantly in humerus and femur confirmed by Raman spectroscopy. Meanwhile, the mineral density and yield load capacities of humerus and femur were improved. This study demonstrated that the high crystallinity and low carbonate substitution were tightly correlated with the relatively enhanced mechanical properties. Moreover, it elucidated biochemical mechanisms of estrogen in regulating mineralogical and mechanical properties of bones in laying hens." @default.
• W2945809301 created "2019-05-29" @default.
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• W2945809301 date "2019-06-01" @default.
• W2945809301 modified "2023-09-25" @default.
• W2945809301 title "Letrozole induced changes in bone mineral properties and mechanical functions of laying hens" @default.
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• W2945809301 doi "https://doi.org/10.3382/ps/pey605" @default.
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