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• W2945831438 startingPage "191" @default.
• W2945831438 abstract "End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers. HIV+ recipients historically experienced 2–4-fold higher rejection. Integrase strand transferase inhibitors (INSTIs) minimize drug interactions and may reduce rejection along with lymphodepleting induction immunosuppression. Hepatitis C virus (HCV) coinfection has been associated with inferior outcomes, yet direct-acting antivirals (DAAs) may mitigate this. Experience in South Africa and the US HIV Organ Policy Equity (HOPE) Act support HIV+ donor to HIV+ recipient (HIV D+/R+) transplantation. SOT is the optimal treatment for end-stage organ disease in HIV+ individuals. Recent advances include use of INSTIs and DAAs in transplant recipients; however, strategies to improve access to transplant are needed. HIV D+/R+ transplantation is under investigation and may improve access and provide insights for HIV cure and pathogenesis research." @default.
• W2945831438 created "2019-05-29" @default.
• W2945831438 creator A5011890756 @default.
• W2945831438 creator A5043750897 @default.
• W2945831438 date "2019-05-16" @default.
• W2945831438 modified "2023-10-13" @default.
• W2945831438 title "Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers" @default.
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