Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945849030> ?p ?o ?g. }
- W2945849030 endingPage "e15527" @default.
- W2945849030 startingPage "e15527" @default.
- W2945849030 abstract "This study is conducted to investigate the association between major depressive disorder and the subsequent development of Alzheimer disease (AD) in elderly patients with different health statuses using Taiwan's National Health Insurance Research Database (NHIRD).A retrospective cohort study was performed on subjects over 65 years old from 2002 to 2006 using a random sampling from the 1 million beneficiaries enrolled in the NHI. Patients who were diagnosed with major depressive disorder were selected as the case group. Subjects in the control group were selected from elderly patients who did not have depression during the study period by matching age, sex, and index date of depression with subjects in the case group using a ratio of 1:4 (case:control). Both groups of patients were checked annually over a period of 7 years to observe whether they subsequently developed AD.A total of 1776 subjects were included in the case group while 7104 subjects were in the control group. After the follow-up period, 59 patients (3.3%) with depression developed AD while 96 patients (1.4%) without depression developed AD. The Kaplan-Meier curves showed that the incidence rate of AD in both groups varied significantly depending on different health statuses (log-rank P < .001). Results of the generalized estimating equation model found that patients with depression (hazard ratio [HR] = 1.898; 95% confidence interval [CI] = 1.451-2.438), very severe health status (HR = 1.630; 95% CI = 1.220-2.177), or artery diseases (HR = 1.692; 95% CI = 1.108-2.584) were at a higher risk of developing AD than other groups.The association between major depressive disorder and the later development of AD varied depending on the health statuses of elderly patients. Clinicians should exercise caution when diagnosing and treating underlying diseases in elderly depressed patients, and then attempt to improve their health status to reduce the incidence rate of subsequent AD development." @default.
- W2945849030 created "2019-05-29" @default.
- W2945849030 creator A5019807517 @default.
- W2945849030 creator A5050314917 @default.
- W2945849030 creator A5074298738 @default.
- W2945849030 creator A5074893294 @default.
- W2945849030 date "2019-05-01" @default.
- W2945849030 modified "2023-10-14" @default.
- W2945849030 title "Development of Alzheimer disease in old major depressive patients based upon their health status" @default.
- W2945849030 cites W1517789775 @default.
- W2945849030 cites W1592902957 @default.
- W2945849030 cites W1761228750 @default.
- W2945849030 cites W1976646105 @default.
- W2945849030 cites W1987307065 @default.
- W2945849030 cites W1997102112 @default.
- W2945849030 cites W2003982930 @default.
- W2945849030 cites W2010630049 @default.
- W2945849030 cites W2016437556 @default.
- W2945849030 cites W2024633135 @default.
- W2945849030 cites W2059533120 @default.
- W2945849030 cites W2069158867 @default.
- W2945849030 cites W2072983755 @default.
- W2945849030 cites W2079861976 @default.
- W2945849030 cites W2086220368 @default.
- W2945849030 cites W2096513004 @default.
- W2945849030 cites W2104778243 @default.
- W2945849030 cites W2113190831 @default.
- W2945849030 cites W2122522567 @default.
- W2945849030 cites W2140684300 @default.
- W2945849030 cites W2142827889 @default.
- W2945849030 cites W2154569902 @default.
- W2945849030 cites W2169878253 @default.
- W2945849030 cites W2285500077 @default.
- W2945849030 cites W2308784387 @default.
- W2945849030 cites W2314408623 @default.
- W2945849030 cites W2758273018 @default.
- W2945849030 cites W4210975612 @default.
- W2945849030 cites W4211135065 @default.
- W2945849030 cites W856442 @default.
- W2945849030 doi "https://doi.org/10.1097/md.0000000000015527" @default.
- W2945849030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6531098" @default.
- W2945849030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31096454" @default.
- W2945849030 hasPublicationYear "2019" @default.
- W2945849030 type Work @default.
- W2945849030 sameAs 2945849030 @default.
- W2945849030 citedByCount "5" @default.
- W2945849030 countsByYear W29458490302020 @default.
- W2945849030 countsByYear W29458490302021 @default.
- W2945849030 countsByYear W29458490302022 @default.
- W2945849030 countsByYear W29458490302023 @default.
- W2945849030 crossrefType "journal-article" @default.
- W2945849030 hasAuthorship W2945849030A5019807517 @default.
- W2945849030 hasAuthorship W2945849030A5050314917 @default.
- W2945849030 hasAuthorship W2945849030A5074298738 @default.
- W2945849030 hasAuthorship W2945849030A5074893294 @default.
- W2945849030 hasBestOaLocation W29458490301 @default.
- W2945849030 hasConcept C120665830 @default.
- W2945849030 hasConcept C121332964 @default.
- W2945849030 hasConcept C126322002 @default.
- W2945849030 hasConcept C139719470 @default.
- W2945849030 hasConcept C144024400 @default.
- W2945849030 hasConcept C149923435 @default.
- W2945849030 hasConcept C162324750 @default.
- W2945849030 hasConcept C167135981 @default.
- W2945849030 hasConcept C187212893 @default.
- W2945849030 hasConcept C201903717 @default.
- W2945849030 hasConcept C207103383 @default.
- W2945849030 hasConcept C2776867660 @default.
- W2945849030 hasConcept C2779134260 @default.
- W2945849030 hasConcept C44249647 @default.
- W2945849030 hasConcept C50382708 @default.
- W2945849030 hasConcept C61511704 @default.
- W2945849030 hasConcept C71924100 @default.
- W2945849030 hasConceptScore W2945849030C120665830 @default.
- W2945849030 hasConceptScore W2945849030C121332964 @default.
- W2945849030 hasConceptScore W2945849030C126322002 @default.
- W2945849030 hasConceptScore W2945849030C139719470 @default.
- W2945849030 hasConceptScore W2945849030C144024400 @default.
- W2945849030 hasConceptScore W2945849030C149923435 @default.
- W2945849030 hasConceptScore W2945849030C162324750 @default.
- W2945849030 hasConceptScore W2945849030C167135981 @default.
- W2945849030 hasConceptScore W2945849030C187212893 @default.
- W2945849030 hasConceptScore W2945849030C201903717 @default.
- W2945849030 hasConceptScore W2945849030C207103383 @default.
- W2945849030 hasConceptScore W2945849030C2776867660 @default.
- W2945849030 hasConceptScore W2945849030C2779134260 @default.
- W2945849030 hasConceptScore W2945849030C44249647 @default.
- W2945849030 hasConceptScore W2945849030C50382708 @default.
- W2945849030 hasConceptScore W2945849030C61511704 @default.
- W2945849030 hasConceptScore W2945849030C71924100 @default.
- W2945849030 hasIssue "20" @default.
- W2945849030 hasLocation W29458490301 @default.
- W2945849030 hasLocation W29458490302 @default.
- W2945849030 hasLocation W29458490303 @default.
- W2945849030 hasLocation W29458490304 @default.
- W2945849030 hasLocation W29458490305 @default.
- W2945849030 hasOpenAccess W2945849030 @default.
- W2945849030 hasPrimaryLocation W29458490301 @default.