FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945851159> ?p ?o ?g. }

• W2945851159 endingPage "101221" @default.
• W2945851159 startingPage "101221" @default.
• W2945851159 abstract "To test our hypothesis that proatherogenic lysophosphatidylcholine (LPC) upregulates trained immunity pathways (TIPs) in human aortic endothelial cells (HAECs), we conducted an intensive analyses on our RNA-Seq data and histone 3 lysine 14 acetylation (H3K14ac)-CHIP-Seq data, both performed on HAEC treated with LPC. Our analysis revealed that: 1) LPC induces upregulation of three TIPs including glycolysis enzymes (GE), mevalonate enzymes (ME), and acetyl-CoA generating enzymes (ACE); 2) LPC induces upregulation of 29% of 31 histone acetyltransferases, three of which acetylate H3K14; 3) LPC induces H3K14 acetylation (H3K14ac) in the genomic DNA that encodes LPC-induced TIP genes (79%) in comparison to that of in LPC-induced effector genes (43%) including ICAM-1; 4) TIP pathways are significantly different from that of EC activation effectors including adhesion molecule ICAM-1; 5) reactive oxygen species generating enzyme NOX2 deficiency decreases, but antioxidant transcription factor Nrf2 deficiency increases, the expressions of a few TIP genes and EC activation effector genes; and 6) LPC induced TIP genes(81%) favor inter-chromosomal long-range interactions (CLRI, trans-chromatin interaction) while LPC induced effector genes (65%) favor intra-chromosomal CLRIs (cis-chromatin interaction). Our findings demonstrated that proatherogenic lipids upregulate TIPs in HAECs, which are a new category of qualification markers for chronic disease risk factors and conditional DAMPs and potential mechanisms for acute inflammation transition to chronic ones. These novel insights may lead to identifications of new cardiovascular risk factors in upregulating TIPs in cardiovascular cells and novel therapeutic targets for the treatment of metabolic cardiovascular diseases, inflammation, and cancers. (total words: 245)." @default.
• W2945851159 created "2019-05-29" @default.
• W2945851159 creator A5003828243 @default.
• W2945851159 creator A5003889511 @default.
• W2945851159 creator A5004145168 @default.
• W2945851159 creator A5004792622 @default.
• W2945851159 creator A5014977626 @default.
• W2945851159 creator A5027354226 @default.
• W2945851159 creator A5027371867 @default.
• W2945851159 creator A5031372799 @default.
• W2945851159 creator A5033020983 @default.
• W2945851159 creator A5038423791 @default.
• W2945851159 creator A5041022925 @default.
• W2945851159 creator A5047172495 @default.
• W2945851159 creator A5063184651 @default.
• W2945851159 creator A5065816864 @default.
• W2945851159 creator A5069971376 @default.
• W2945851159 creator A5083680911 @default.
• W2945851159 date "2019-06-01" @default.
• W2945851159 modified "2023-10-15" @default.
• W2945851159 title "Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs" @default.
• W2945851159 cites W1553155385 @default.
• W2945851159 cites W1766991754 @default.
• W2945851159 cites W1963740134 @default.
• W2945851159 cites W1965734808 @default.
• W2945851159 cites W1969849879 @default.
• W2945851159 cites W1979353111 @default.
• W2945851159 cites W1987453453 @default.
• W2945851159 cites W1988577959 @default.
• W2945851159 cites W1991274029 @default.
• W2945851159 cites W1994675489 @default.
• W2945851159 cites W2000438836 @default.
• W2945851159 cites W2009576540 @default.
• W2945851159 cites W2019447967 @default.
• W2945851159 cites W2024843655 @default.
• W2945851159 cites W2038286032 @default.
• W2945851159 cites W2045799105 @default.
• W2945851159 cites W2067031028 @default.
• W2945851159 cites W2071041688 @default.
• W2945851159 cites W2073026107 @default.
• W2945851159 cites W2077792952 @default.
• W2945851159 cites W2084299658 @default.
• W2945851159 cites W2084317828 @default.
• W2945851159 cites W2099912006 @default.
• W2945851159 cites W2108447811 @default.
• W2945851159 cites W2111195270 @default.
• W2945851159 cites W2121076832 @default.
• W2945851159 cites W2126604626 @default.
• W2945851159 cites W2135113543 @default.
• W2945851159 cites W2147568705 @default.
• W2945851159 cites W2147959669 @default.
• W2945851159 cites W2154746182 @default.
• W2945851159 cites W2162143298 @default.
• W2945851159 cites W2169456326 @default.
• W2945851159 cites W2185236314 @default.
• W2945851159 cites W2229054234 @default.
• W2945851159 cites W2229349208 @default.
• W2945851159 cites W2289998244 @default.
• W2945851159 cites W2304527713 @default.
• W2945851159 cites W2327905865 @default.
• W2945851159 cites W2336177638 @default.
• W2945851159 cites W2336656712 @default.
• W2945851159 cites W2342393790 @default.
• W2945851159 cites W2398302267 @default.
• W2945851159 cites W2415154340 @default.
• W2945851159 cites W2530446499 @default.
• W2945851159 cites W2552379875 @default.
• W2945851159 cites W2555174400 @default.
• W2945851159 cites W2557169014 @default.
• W2945851159 cites W2577474303 @default.
• W2945851159 cites W2614986146 @default.
• W2945851159 cites W2772137331 @default.
• W2945851159 cites W2778507522 @default.
• W2945851159 cites W2782649526 @default.
• W2945851159 cites W2787590216 @default.
• W2945851159 cites W2793208817 @default.
• W2945851159 cites W2796385350 @default.
• W2945851159 cites W2804127388 @default.
• W2945851159 cites W2805705799 @default.
• W2945851159 cites W2841660058 @default.
• W2945851159 cites W2889763022 @default.
• W2945851159 cites W2895522259 @default.
• W2945851159 cites W2901827774 @default.
• W2945851159 cites W2908597227 @default.
• W2945851159 cites W2909347958 @default.
• W2945851159 cites W2909419338 @default.
• W2945851159 cites W2909658493 @default.
• W2945851159 cites W2910765752 @default.
• W2945851159 cites W2911741918 @default.
• W2945851159 cites W2912839621 @default.
• W2945851159 cites W2913535368 @default.
• W2945851159 cites W4233310067 @default.
• W2945851159 cites W4243715563 @default.
• W2945851159 doi "https://doi.org/10.1016/j.redox.2019.101221" @default.
• W2945851159 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6543097" @default.
• W2945851159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31153039" @default.
• W2945851159 hasPublicationYear "2019" @default.
• W2945851159 type Work @default.

• next