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- W2945858082 abstract "Quantitation of thromboembolism is necessary to guide polymer fabrication and anticoagulant use for artificial organ implantation. Therefore as part of the LVAD program we have solid-phase radioiodinated bovine fibrinogen and developed an autologous 111In technique to quantitate platelet survival. Mean platelet survival time(n/a) by the method of Murphy and Francis was 130±20 hrs for 10 animals; platelet aggregation and serotonin release were unaffected by the labelling procedure, n/a for homologous fibrinogen was 55.0±7.3 hrs. for 11 cows; clottability was 93%. LVAD implantation of the Thoratec Model VIC devices with textured surfaces produced both shortened platelet (47+4.4 hrs.) and fibrinogen survival (30±4.6 hrs.) at 24 hrs. despite coumadin, aspirin and persantin. Survival curves changed from linear to curvilinear, suggesting consumption. Sequential studies at 1, 2 and 4 weeks showed continued platelet and fibrinogen consumption though to lesser degrees than at 24 hrs. Despite coumadin, aspirin and persantin, on-going consumption is occurring and can be quantitated, thereby providing a laboratory monitor to guide future development and clinical use of the LVAD." @default.
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- W2945858082 date "1979-01-01" @default.
- W2945858082 modified "2023-09-26" @default.
- W2945858082 title "Sequential Platelet and Fibrinogen Turnover Studies Associated with left Ventricular Assist Device (LVAD) Implantation" @default.
- W2945858082 doi "https://doi.org/10.1055/s-0039-1684440" @default.
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