Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945884870> ?p ?o ?g. }
- W2945884870 endingPage "20" @default.
- W2945884870 startingPage "12" @default.
- W2945884870 abstract "Expression of the zinc receptor, ZnR/GPR39, is increased in higher grade breast cancer tumors and cells. Zinc, its ligand, is accumulated at larger concentrations in the tumor tissue and can therefore activate ZnR/GPR39-dependent Ca2+ signaling leading to tumor progression. The K+/Cl− co-transporters (KCC), activated by intracellular signaling, enhance breast cancer cell migration and invasion. We asked if ZnR/GPR39 enhances breast cancer cell malignancy by activating KCC. Activation of ZnR/GPR39 by Zn2+ upregulated K+/Cl− co-transport activity, measured using NH4+ as a surrogate to K+ while monitoring intracellular pH. Upregulation of NH4+ transport was monitored in tamoxifen resistant cells with functional ZnR/GPR39-dependent Ca2+ signaling but not in MCF-7 cells lacking this response. The NH4+ transport was Na+-independent, and we therefore focused on KCC family members. Silencing of KCC3, but not KCC4, expression abolished Zn2+-dependent K+/Cl− co-transport, suggesting that KCC3 is mediating upregulated NH4+ transport. The ZnR/GPR39-dependent KCC3 activation accelerated scratch closure rate, which was abolished by inhibiting KCC transport with [(DihydroIndenyl) Oxy] Alkanoic acid (DIOA). Importantly, silencing of either ZnR/GPR39 or KCC3 attenuated Zn2+-dependent scratch closure. Thus, a novel link between KCC3 and Zn2+, via ZnR/GPR39, promotes breast cancer cell migration and proliferation." @default.
- W2945884870 created "2019-05-29" @default.
- W2945884870 creator A5001491735 @default.
- W2945884870 creator A5026257182 @default.
- W2945884870 creator A5045420328 @default.
- W2945884870 creator A5070157010 @default.
- W2945884870 creator A5072422287 @default.
- W2945884870 date "2019-07-01" @default.
- W2945884870 modified "2023-10-15" @default.
- W2945884870 title "ZnR/GPR39 upregulation of K+/Cl−-cotransporter 3 in tamoxifen resistant breast cancer cells" @default.
- W2945884870 cites W1497207210 @default.
- W2945884870 cites W1500220560 @default.
- W2945884870 cites W1969048961 @default.
- W2945884870 cites W1971517985 @default.
- W2945884870 cites W1979067350 @default.
- W2945884870 cites W1982365817 @default.
- W2945884870 cites W1999526269 @default.
- W2945884870 cites W1999594546 @default.
- W2945884870 cites W2004339821 @default.
- W2945884870 cites W2014148051 @default.
- W2945884870 cites W2015896990 @default.
- W2945884870 cites W2019874622 @default.
- W2945884870 cites W2025005089 @default.
- W2945884870 cites W2026467905 @default.
- W2945884870 cites W2028719771 @default.
- W2945884870 cites W2037081631 @default.
- W2945884870 cites W2049286220 @default.
- W2945884870 cites W2052815854 @default.
- W2945884870 cites W2053080879 @default.
- W2945884870 cites W2053542749 @default.
- W2945884870 cites W2054638593 @default.
- W2945884870 cites W2058971048 @default.
- W2945884870 cites W2068079108 @default.
- W2945884870 cites W2069451604 @default.
- W2945884870 cites W2078134576 @default.
- W2945884870 cites W2080926454 @default.
- W2945884870 cites W2085997938 @default.
- W2945884870 cites W2086993029 @default.
- W2945884870 cites W2091515727 @default.
- W2945884870 cites W2095208806 @default.
- W2945884870 cites W2095666256 @default.
- W2945884870 cites W2111324624 @default.
- W2945884870 cites W2125744401 @default.
- W2945884870 cites W2125971675 @default.
- W2945884870 cites W2131462893 @default.
- W2945884870 cites W2146972155 @default.
- W2945884870 cites W2159366883 @default.
- W2945884870 cites W2159909833 @default.
- W2945884870 cites W2170033050 @default.
- W2945884870 cites W2210666147 @default.
- W2945884870 cites W2228574729 @default.
- W2945884870 cites W2257401992 @default.
- W2945884870 cites W2579487217 @default.
- W2945884870 cites W2586422690 @default.
- W2945884870 cites W2588460700 @default.
- W2945884870 cites W2606737642 @default.
- W2945884870 cites W2614543224 @default.
- W2945884870 cites W2725530316 @default.
- W2945884870 cites W2754088161 @default.
- W2945884870 cites W2804064865 @default.
- W2945884870 cites W2807492122 @default.
- W2945884870 cites W2886235471 @default.
- W2945884870 cites W2919848598 @default.
- W2945884870 cites W2921921390 @default.
- W2945884870 doi "https://doi.org/10.1016/j.ceca.2019.05.005" @default.
- W2945884870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31146164" @default.
- W2945884870 hasPublicationYear "2019" @default.
- W2945884870 type Work @default.
- W2945884870 sameAs 2945884870 @default.
- W2945884870 citedByCount "16" @default.
- W2945884870 countsByYear W29458848702020 @default.
- W2945884870 countsByYear W29458848702021 @default.
- W2945884870 countsByYear W29458848702022 @default.
- W2945884870 countsByYear W29458848702023 @default.
- W2945884870 crossrefType "journal-article" @default.
- W2945884870 hasAuthorship W2945884870A5001491735 @default.
- W2945884870 hasAuthorship W2945884870A5026257182 @default.
- W2945884870 hasAuthorship W2945884870A5045420328 @default.
- W2945884870 hasAuthorship W2945884870A5070157010 @default.
- W2945884870 hasAuthorship W2945884870A5072422287 @default.
- W2945884870 hasBestOaLocation W29458848702 @default.
- W2945884870 hasConcept C104317684 @default.
- W2945884870 hasConcept C119056186 @default.
- W2945884870 hasConcept C121608353 @default.
- W2945884870 hasConcept C126322002 @default.
- W2945884870 hasConcept C127561419 @default.
- W2945884870 hasConcept C134018914 @default.
- W2945884870 hasConcept C185592680 @default.
- W2945884870 hasConcept C2777176818 @default.
- W2945884870 hasConcept C502942594 @default.
- W2945884870 hasConcept C530470458 @default.
- W2945884870 hasConcept C54355233 @default.
- W2945884870 hasConcept C55493867 @default.
- W2945884870 hasConcept C71924100 @default.
- W2945884870 hasConcept C79879829 @default.
- W2945884870 hasConcept C81885089 @default.
- W2945884870 hasConcept C86803240 @default.
- W2945884870 hasConcept C95444343 @default.