Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945887480> ?p ?o ?g. }
- W2945887480 abstract "Abstract Biodosimetry-based discrimination between homogeneous total-body photon exposure and complex irradiation scenarios (partial-body shielding and/or neutron + photon mixtures) can improve treatment decisions after mass-casualty radiation-related incidents. Our study objective was to use high-throughput biomarkers to: a) detect partial-body and/or neutron exposure on an individual basis, and b) estimate separately the photon and neutron doses in a mixed exposure. We developed a novel approach, where metrics related to the shapes of micronuclei distributions per binucleated cell in ex-vivo irradiated human lymphocytes (variance/mean, kurtosis, skewness, etc .) served as predictors in machine learning or parametric analyses of the following scenarios: (A) Homogeneous gamma-irradiation, mimicking total-body exposures, vs. mixtures of irradiated blood with unirradiated blood, mimicking partial-body exposures. (B) X rays vs. various neutron + photon mixtures. Classification of samples as homogeneously vs. heterogeneously irradiated (scenario A) achieved a receiver operating characteristic curve area (AUROC) of 0.931 (uncertainty range of 0.903-0.951), and R 2 for actual vs. reconstructed mean dose was 0.87. Detection of samples with ≥10% neutron contribution (scenario B) achieved AUROC of 0.916 (0.893-0.943), and R 2 for reconstructing photon-equivalent dose was 0.77. These encouraging findings demonstrate a proof-of-principle for the proposed approach of analyzing micronuclei/cell distributions to detect clinically-relevant complex radiation exposure scenarios." @default.
- W2945887480 created "2019-05-29" @default.
- W2945887480 creator A5000838527 @default.
- W2945887480 creator A5008919275 @default.
- W2945887480 creator A5020999531 @default.
- W2945887480 creator A5022216920 @default.
- W2945887480 creator A5028852323 @default.
- W2945887480 creator A5040126130 @default.
- W2945887480 creator A5040769020 @default.
- W2945887480 creator A5044358814 @default.
- W2945887480 creator A5045987646 @default.
- W2945887480 creator A5048201953 @default.
- W2945887480 creator A5090464230 @default.
- W2945887480 date "2019-05-23" @default.
- W2945887480 modified "2023-09-30" @default.
- W2945887480 title "New High Throughput Approaches to Detect Partial-body and Neutron Exposures on an Individual Basis" @default.
- W2945887480 cites W1586199762 @default.
- W2945887480 cites W1920810040 @default.
- W2945887480 cites W1946597462 @default.
- W2945887480 cites W1966402423 @default.
- W2945887480 cites W1969216720 @default.
- W2945887480 cites W1972532335 @default.
- W2945887480 cites W2004368065 @default.
- W2945887480 cites W2005294261 @default.
- W2945887480 cites W2018146171 @default.
- W2945887480 cites W2029228182 @default.
- W2945887480 cites W2040055442 @default.
- W2945887480 cites W2042768649 @default.
- W2945887480 cites W2054489583 @default.
- W2945887480 cites W2079029583 @default.
- W2945887480 cites W2085011320 @default.
- W2945887480 cites W2085534751 @default.
- W2945887480 cites W2092926610 @default.
- W2945887480 cites W2103828219 @default.
- W2945887480 cites W2126233282 @default.
- W2945887480 cites W2132445811 @default.
- W2945887480 cites W2137173001 @default.
- W2945887480 cites W2144554917 @default.
- W2945887480 cites W2149799562 @default.
- W2945887480 cites W2153515466 @default.
- W2945887480 cites W2188909156 @default.
- W2945887480 cites W2209923776 @default.
- W2945887480 cites W2408292805 @default.
- W2945887480 cites W250309793 @default.
- W2945887480 cites W2508262604 @default.
- W2945887480 cites W2510465102 @default.
- W2945887480 cites W2528070793 @default.
- W2945887480 cites W2548287259 @default.
- W2945887480 cites W2564333599 @default.
- W2945887480 cites W2610337600 @default.
- W2945887480 cites W2611665552 @default.
- W2945887480 cites W2773522953 @default.
- W2945887480 cites W2779791576 @default.
- W2945887480 cites W2794772181 @default.
- W2945887480 cites W2801561824 @default.
- W2945887480 cites W2806779099 @default.
- W2945887480 cites W2810868414 @default.
- W2945887480 cites W2901150773 @default.
- W2945887480 cites W2922507497 @default.
- W2945887480 cites W2935373262 @default.
- W2945887480 cites W2941073861 @default.
- W2945887480 cites W3215186461 @default.
- W2945887480 cites W355324028 @default.
- W2945887480 doi "https://doi.org/10.1101/646711" @default.
- W2945887480 hasPublicationYear "2019" @default.
- W2945887480 type Work @default.
- W2945887480 sameAs 2945887480 @default.
- W2945887480 citedByCount "0" @default.
- W2945887480 crossrefType "posted-content" @default.
- W2945887480 hasAuthorship W2945887480A5000838527 @default.
- W2945887480 hasAuthorship W2945887480A5008919275 @default.
- W2945887480 hasAuthorship W2945887480A5020999531 @default.
- W2945887480 hasAuthorship W2945887480A5022216920 @default.
- W2945887480 hasAuthorship W2945887480A5028852323 @default.
- W2945887480 hasAuthorship W2945887480A5040126130 @default.
- W2945887480 hasAuthorship W2945887480A5040769020 @default.
- W2945887480 hasAuthorship W2945887480A5044358814 @default.
- W2945887480 hasAuthorship W2945887480A5045987646 @default.
- W2945887480 hasAuthorship W2945887480A5048201953 @default.
- W2945887480 hasAuthorship W2945887480A5090464230 @default.
- W2945887480 hasBestOaLocation W29458874801 @default.
- W2945887480 hasConcept C105795698 @default.
- W2945887480 hasConcept C111337013 @default.
- W2945887480 hasConcept C120665830 @default.
- W2945887480 hasConcept C121332964 @default.
- W2945887480 hasConcept C136229726 @default.
- W2945887480 hasConcept C152568617 @default.
- W2945887480 hasConcept C153385146 @default.
- W2945887480 hasConcept C166963901 @default.
- W2945887480 hasConcept C18231593 @default.
- W2945887480 hasConcept C185544564 @default.
- W2945887480 hasConcept C186060115 @default.
- W2945887480 hasConcept C192562407 @default.
- W2945887480 hasConcept C2779254040 @default.
- W2945887480 hasConcept C2989005 @default.
- W2945887480 hasConcept C33923547 @default.
- W2945887480 hasConcept C71924100 @default.
- W2945887480 hasConcept C86803240 @default.
- W2945887480 hasConceptScore W2945887480C105795698 @default.
- W2945887480 hasConceptScore W2945887480C111337013 @default.