Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945889886> ?p ?o ?g. }
- W2945889886 endingPage "285" @default.
- W2945889886 startingPage "276" @default.
- W2945889886 abstract "Abstract The cellular immunotherapy field has achieved important milestones in the last 30 years towards the treatment of a variety of cancers due to improvements in ex-vivo T cell manufacturing processes, the invention of synthetic T cell receptors, and advances in cellular engineering. Here, we discuss major preclinical models that have been useful for the validation of chimeric antigen receptor (CAR)-T cell therapies and also promising new models that will fuel future investigations towards success. However, multiple unanswered questions in the CAR-T cell field remain to be addressed that will require innovative preclinical models. Key challenges facing the field include premature immune rejection of universal CAR-T cells and the immune suppressive tumor microenvironment. Immune competent models that accurately recapitulate tumor heterogeneity, the hostile tumor microenvironment, and barriers to CAR-T cell homing, toxicity, and persistence are needed for further advancement of the field." @default.
- W2945889886 created "2019-05-29" @default.
- W2945889886 creator A5081974926 @default.
- W2945889886 creator A5087804855 @default.
- W2945889886 creator A5089193809 @default.
- W2945889886 date "2018-01-01" @default.
- W2945889886 modified "2023-10-16" @default.
- W2945889886 title "Keeping the Engine Running: The Relevance and Predictive Value of Preclinical Models for CAR-T Cell Development" @default.
- W2945889886 cites W1546448788 @default.
- W2945889886 cites W1842126375 @default.
- W2945889886 cites W1859254390 @default.
- W2945889886 cites W1896894041 @default.
- W2945889886 cites W1922135726 @default.
- W2945889886 cites W1965498936 @default.
- W2945889886 cites W1967517831 @default.
- W2945889886 cites W1975658333 @default.
- W2945889886 cites W1981308462 @default.
- W2945889886 cites W1988804393 @default.
- W2945889886 cites W1989273697 @default.
- W2945889886 cites W1992995822 @default.
- W2945889886 cites W1994772304 @default.
- W2945889886 cites W1995399277 @default.
- W2945889886 cites W1997231656 @default.
- W2945889886 cites W1997662788 @default.
- W2945889886 cites W2001079563 @default.
- W2945889886 cites W2002001086 @default.
- W2945889886 cites W2007987850 @default.
- W2945889886 cites W2019637349 @default.
- W2945889886 cites W2019904910 @default.
- W2945889886 cites W2020312840 @default.
- W2945889886 cites W2027038674 @default.
- W2945889886 cites W2028417270 @default.
- W2945889886 cites W2028460943 @default.
- W2945889886 cites W2034978970 @default.
- W2945889886 cites W2040149014 @default.
- W2945889886 cites W2045475405 @default.
- W2945889886 cites W2047205338 @default.
- W2945889886 cites W2049790267 @default.
- W2945889886 cites W2059698874 @default.
- W2945889886 cites W2065236789 @default.
- W2945889886 cites W2068302119 @default.
- W2945889886 cites W2070748533 @default.
- W2945889886 cites W2094945699 @default.
- W2945889886 cites W2099958672 @default.
- W2945889886 cites W2102207725 @default.
- W2945889886 cites W2104342628 @default.
- W2945889886 cites W2105400883 @default.
- W2945889886 cites W2105879190 @default.
- W2945889886 cites W2107306736 @default.
- W2945889886 cites W2108465905 @default.
- W2945889886 cites W2110260408 @default.
- W2945889886 cites W2114147900 @default.
- W2945889886 cites W2118796952 @default.
- W2945889886 cites W2120020619 @default.
- W2945889886 cites W2121740832 @default.
- W2945889886 cites W2125524975 @default.
- W2945889886 cites W2128310039 @default.
- W2945889886 cites W2130011407 @default.
- W2945889886 cites W2133298966 @default.
- W2945889886 cites W2135428178 @default.
- W2945889886 cites W2143626441 @default.
- W2945889886 cites W2145254159 @default.
- W2945889886 cites W2145985838 @default.
- W2945889886 cites W2151241056 @default.
- W2945889886 cites W2151351958 @default.
- W2945889886 cites W2154115071 @default.
- W2945889886 cites W2179454156 @default.
- W2945889886 cites W2239894385 @default.
- W2945889886 cites W2268311328 @default.
- W2945889886 cites W2340435799 @default.
- W2945889886 cites W2370602852 @default.
- W2945889886 cites W2400439118 @default.
- W2945889886 cites W2465431026 @default.
- W2945889886 cites W2513573571 @default.
- W2945889886 cites W2526282664 @default.
- W2945889886 cites W2561919135 @default.
- W2945889886 cites W2584556365 @default.
- W2945889886 cites W2606325744 @default.
- W2945889886 cites W2607488814 @default.
- W2945889886 cites W2610389172 @default.
- W2945889886 cites W2612001965 @default.
- W2945889886 cites W2624444817 @default.
- W2945889886 cites W2738678436 @default.
- W2945889886 cites W2754272966 @default.
- W2945889886 cites W2754562068 @default.
- W2945889886 cites W2759643796 @default.
- W2945889886 cites W2763751953 @default.
- W2945889886 cites W2766903152 @default.
- W2945889886 cites W2768823259 @default.
- W2945889886 cites W2770704851 @default.
- W2945889886 cites W2773804840 @default.
- W2945889886 cites W2775090445 @default.
- W2945889886 cites W2781447571 @default.
- W2945889886 cites W2782685657 @default.
- W2945889886 cites W2787301955 @default.
- W2945889886 cites W2787621143 @default.
- W2945889886 cites W2789914923 @default.
- W2945889886 cites W2791660181 @default.