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• W2945890701 abstract "Recruitment of leukocytes exhibiting arguable and ambiguous processes is involved in the inflammatory response, a specific reaction of organisms to tissue damage. Tracking leukocytes is of great importance for understanding the recruitment of leukocytes. Here, we report the fabrication of carboxyl silane and TAT cell-penetrating peptide-functionalized near-infrared-emitting persistent luminescence nanoparticles (PLNP-TAT) with deep tissue penetration in bioimaging for autofluorescence-free tracking of J774A.1 macrophages homing to inflamed tissues. The PLNP-TAT enables effective labeling of the J774A.1 macrophages and the tracking of the migration of cells to the simulated endothelial inflammatory microenvironment in vitro. Moreover, the PLNP-TAT also allows the tracking of J774A.1 macrophages homing to inflamed tissues in vivo under discontinuous illumination with a red light-emitting diode light. The PLNP-TAT allows in vivo tracking of leukocytes without the need for conventional continuous excitation and offers great potential in cell-tracking and diagnostic applications without the autofluorescence background and thermal damages brought about by continuous excitation." @default.
• W2945890701 created "2019-05-29" @default.
• W2945890701 creator A5049967413 @default.
• W2945890701 creator A5057585686 @default.
• W2945890701 creator A5090486781 @default.
• W2945890701 date "2019-05-13" @default.
• W2945890701 modified "2023-10-16" @default.
• W2945890701 title "Cell-Penetrating Peptide-Functionalized Persistent Luminescence Nanoparticles for Tracking J774A.1 Macrophages Homing to Inflamed Tissues" @default.
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• W2945890701 doi "https://doi.org/10.1021/acsami.9b05870" @default.
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