FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945904570> ?p ?o ?g. }

• W2945904570 endingPage "307" @default.
• W2945904570 startingPage "296" @default.
• W2945904570 abstract "Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. In current dogma, pathogenesis of IBD is attributed to the dysregulated mucosal immune response to gut flora in genetically susceptible individuals, but the genetics evidence from GWAS studies so far is insufficient to explain the observed heritability in IBD. For this discordance, epigenetics has emerged to be one of the important causes. Recent studies have reported that histone acetylation is correlated with the development of IBD, whereas its role and underlying molecular mechanism in the disease still remain elusive. Here, we established a dextran sulfate sodium (DSS)-induced chronic colitis model and performed RNA-sequencing (RNA-seq) and Chromatin Immunoprecipitation followed by NGS sequencing (ChIP-seq) for H3K27ac in the mice colon tissues to investigate whether H3K27ac is involved in the development of intestinal inflammation. We found that the global H3K27ac level and distribution in colon tissue had no significant difference after DSS treatment, while H3K27ac signals were significantly enriched in the typical-enhancers of the DSS group compared with the control. By combining with RNA-seq data (fold change >2), we identified 56 candidate genes as potential target genes for H3K27ac change upon DSS treatment. We further predicted transcription factors (TFs) involved in DSS-induced colitis according to the enhancers with increased H3K27ac. H3K27ac increase in special typical-enhancers in the DSS group is possibly related to the development of intestinal inflammation by up-regulating adjacent gene expression and shifting TF networks, which will provide new insight into the pathogenesis and therapy of IBD." @default.
• W2945904570 created "2019-05-29" @default.
• W2945904570 creator A5000474356 @default.
• W2945904570 creator A5022557126 @default.
• W2945904570 creator A5024845093 @default.
• W2945904570 creator A5028932455 @default.
• W2945904570 creator A5037829735 @default.
• W2945904570 creator A5039415114 @default.
• W2945904570 creator A5044766614 @default.
• W2945904570 creator A5077540484 @default.
• W2945904570 date "2019-01-01" @default.
• W2945904570 modified "2023-10-04" @default.
• W2945904570 title "Profiling of histone 3 lysine 27 acetylation reveals its role in a chronic DSS-induced colitis mouse model" @default.
• W2945904570 cites W1182237937 @default.
• W2945904570 cites W1486724483 @default.
• W2945904570 cites W1963981640 @default.
• W2945904570 cites W1968142189 @default.
• W2945904570 cites W1969466735 @default.
• W2945904570 cites W1971578941 @default.
• W2945904570 cites W1972181872 @default.
• W2945904570 cites W1973020652 @default.
• W2945904570 cites W1978795069 @default.
• W2945904570 cites W1980071130 @default.
• W2945904570 cites W1981030303 @default.
• W2945904570 cites W1986586739 @default.
• W2945904570 cites W2037746176 @default.
• W2945904570 cites W2047559139 @default.
• W2945904570 cites W2060484997 @default.
• W2945904570 cites W2063786362 @default.
• W2945904570 cites W2067922543 @default.
• W2945904570 cites W2070743682 @default.
• W2945904570 cites W2084160423 @default.
• W2945904570 cites W2087257489 @default.
• W2945904570 cites W2087621970 @default.
• W2945904570 cites W2106625155 @default.
• W2945904570 cites W2109305602 @default.
• W2945904570 cites W2119795339 @default.
• W2945904570 cites W2128151873 @default.
• W2945904570 cites W2130907138 @default.
• W2945904570 cites W2138319875 @default.
• W2945904570 cites W2143625465 @default.
• W2945904570 cites W2147530983 @default.
• W2945904570 cites W2156874253 @default.
• W2945904570 cites W2162217523 @default.
• W2945904570 cites W2163521888 @default.
• W2945904570 cites W2163884419 @default.
• W2945904570 cites W2172028952 @default.
• W2945904570 cites W2207084272 @default.
• W2945904570 cites W2273920208 @default.
• W2945904570 cites W2287459943 @default.
• W2945904570 cites W2316560853 @default.
• W2945904570 cites W2322032404 @default.
• W2945904570 cites W2475941856 @default.
• W2945904570 cites W2485997503 @default.
• W2945904570 cites W2517826683 @default.
• W2945904570 cites W2533370655 @default.
• W2945904570 cites W2533422282 @default.
• W2945904570 cites W2554912119 @default.
• W2945904570 cites W2571503386 @default.
• W2945904570 cites W2587617032 @default.
• W2945904570 cites W2601176113 @default.
• W2945904570 cites W2601211966 @default.
• W2945904570 cites W2606166588 @default.
• W2945904570 cites W2607002395 @default.
• W2945904570 cites W2609793658 @default.
• W2945904570 cites W2620756707 @default.
• W2945904570 cites W2764244742 @default.
• W2945904570 cites W2802765514 @default.
• W2945904570 cites W3009538581 @default.
• W2945904570 doi "https://doi.org/10.1039/c9mo00070d" @default.
• W2945904570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31147658" @default.
• W2945904570 hasPublicationYear "2019" @default.
• W2945904570 type Work @default.
• W2945904570 sameAs 2945904570 @default.
• W2945904570 citedByCount "5" @default.
• W2945904570 countsByYear W29459045702021 @default.
• W2945904570 countsByYear W29459045702022 @default.
• W2945904570 countsByYear W29459045702023 @default.
• W2945904570 crossrefType "journal-article" @default.
• W2945904570 hasAuthorship W2945904570A5000474356 @default.
• W2945904570 hasAuthorship W2945904570A5022557126 @default.
• W2945904570 hasAuthorship W2945904570A5024845093 @default.
• W2945904570 hasAuthorship W2945904570A5028932455 @default.
• W2945904570 hasAuthorship W2945904570A5037829735 @default.
• W2945904570 hasAuthorship W2945904570A5039415114 @default.
• W2945904570 hasAuthorship W2945904570A5044766614 @default.
• W2945904570 hasAuthorship W2945904570A5077540484 @default.
• W2945904570 hasConcept C101762097 @default.
• W2945904570 hasConcept C104317684 @default.
• W2945904570 hasConcept C111936080 @default.
• W2945904570 hasConcept C126322002 @default.
• W2945904570 hasConcept C150194340 @default.
• W2945904570 hasConcept C203014093 @default.
• W2945904570 hasConcept C2775862500 @default.
• W2945904570 hasConcept C2778260677 @default.
• W2945904570 hasConcept C2779134260 @default.
• W2945904570 hasConcept C2780914512 @default.
• W2945904570 hasConcept C2780942790 @default.

• next