Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945914965> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2945914965 abstract "Peripheral glucagon-like peptide-1 (GLP-1) is a hormone secreted by mucosal cells of the gut. It affects glucose metabolism and gastrointestinal functions, but has also been proposed to take part in the control of food intake. Exogenous GLP-1 administration has been shown to decrease food intake under various conditions. However, the physiological site of action of intestinal GLP-1 to reduce food intake is still unclear.We therefore performed studies in rats to investigate the effects of intraperitoneal (IP) GLP-1 administrations on food intake and to identify the afferent signalling pathway and the brain areas involved. We found that 10, 30 and 90 nmol/kg GLP-1 reduced meal size, but not in a clearly dose-related manner. As the eating-inhibitory effect of IP GLP-1 was attenuated by subdiaphragmatic vagal deafferentation, we conclude that vagal afferents are involved. To determine the brain regions activated by IP GLP-1, we applied c- Fos immunohistochemistry and found neuronal activation in the caudomedial part of the nucleus tractus solitarii (NTS) and in the caudal part of the central nucleus of the amygdala (CeA). The NTS activation by GLP-1 supports a role of vagal afferents in the mediation of GLP-1’s satiating effect. Whether the CeA activation reflects satiation or aversion remains to be identified.To better understand the signalling pathways and to clarify the physiological relevance of peripheral GLP-1 in satiation, however, further investigations are required. Peripheres Glucagon-like Peptide-1 und SattigungPeripheres Glucagon-like peptide-1 (GLP-1) wird von Mucosazellen des Darmes sezerniert. Es beeinflusst den Glucosestoffwechsel und gastrointestinale Funktionen, soll aber auch zur Steuerung des Verzehrs beitragen. Die parenterale Verabreichung von GLP-1 reduziert den Verzehr unter verschiedenen Bedingungen. Der physiologische Wirkungsort von intestinalem GLP-1 ist bisher jedoch unbekannt.Wir fuhrten Studien an Ratten durch, um die Effekte von intraperitoneal (IP) appliziertem GLP-1 auf den Verzehr zu untersuchen und die involvierten afferenten Signalwege und Hirnareale zu identifizieren. Dabei reduzierten 10, 30 und 90 nmol/kg GLP-1 die Mahlzeitengrosse, ohne dass eine klare Dosisabhangigkeit dieses Effekts feststellbar war. Da der verzehrshemmende Effekt von IP infundiertem GLP-1 nach subdiaphragmatischer vagaler Deafferentation abgeschwacht war, sind offenbar vagale Afferenzen involviert. Mit c-Fos Immunohistochemie fanden wir, dass IP appliziertes GLP-1 Neuronen im caudomedialen Teil des Nucleus tractus solitarii (NTS) und im caudalen Teil des zentralen Nucleus der Amygdala (CeA) aktiviert. Die NTS- Aktivierung durch GLP-1 spricht ebenfalls fur eine Rolle der vagalen Afferenzen bei der Vermittlung des Sattigungseffekts. Ob die CeA-Aktivierung Sattigung oder Ubelkeit widerspiegelt, bleibt zu untersuchen.Um die Signalwege besser zu verstehen und die physiologische Relevanz von peripherem GLP-1 fur die Sattigung zu klaren, sind weitere Studien notig." @default.
- W2945914965 created "2019-05-29" @default.
- W2945914965 creator A5076578863 @default.
- W2945914965 date "2010-01-01" @default.
- W2945914965 modified "2023-09-25" @default.
- W2945914965 title "Peripheral glucagon-like peptide-1 and satiation" @default.
- W2945914965 doi "https://doi.org/10.5167/uzh-163933" @default.
- W2945914965 hasPublicationYear "2010" @default.
- W2945914965 type Work @default.
- W2945914965 sameAs 2945914965 @default.
- W2945914965 citedByCount "0" @default.
- W2945914965 crossrefType "dissertation" @default.
- W2945914965 hasAuthorship W2945914965A5076578863 @default.
- W2945914965 hasConcept C126322002 @default.
- W2945914965 hasConcept C134018914 @default.
- W2945914965 hasConcept C169760540 @default.
- W2945914965 hasConcept C170493617 @default.
- W2945914965 hasConcept C2776398474 @default.
- W2945914965 hasConcept C2777180221 @default.
- W2945914965 hasConcept C2777426569 @default.
- W2945914965 hasConcept C2777593968 @default.
- W2945914965 hasConcept C2778395965 @default.
- W2945914965 hasConcept C2778563252 @default.
- W2945914965 hasConcept C2779144063 @default.
- W2945914965 hasConcept C2779281246 @default.
- W2945914965 hasConcept C2779929655 @default.
- W2945914965 hasConcept C2781219945 @default.
- W2945914965 hasConcept C46762472 @default.
- W2945914965 hasConcept C49039625 @default.
- W2945914965 hasConcept C55493867 @default.
- W2945914965 hasConcept C555293320 @default.
- W2945914965 hasConcept C71315377 @default.
- W2945914965 hasConcept C71924100 @default.
- W2945914965 hasConcept C86803240 @default.
- W2945914965 hasConceptScore W2945914965C126322002 @default.
- W2945914965 hasConceptScore W2945914965C134018914 @default.
- W2945914965 hasConceptScore W2945914965C169760540 @default.
- W2945914965 hasConceptScore W2945914965C170493617 @default.
- W2945914965 hasConceptScore W2945914965C2776398474 @default.
- W2945914965 hasConceptScore W2945914965C2777180221 @default.
- W2945914965 hasConceptScore W2945914965C2777426569 @default.
- W2945914965 hasConceptScore W2945914965C2777593968 @default.
- W2945914965 hasConceptScore W2945914965C2778395965 @default.
- W2945914965 hasConceptScore W2945914965C2778563252 @default.
- W2945914965 hasConceptScore W2945914965C2779144063 @default.
- W2945914965 hasConceptScore W2945914965C2779281246 @default.
- W2945914965 hasConceptScore W2945914965C2779929655 @default.
- W2945914965 hasConceptScore W2945914965C2781219945 @default.
- W2945914965 hasConceptScore W2945914965C46762472 @default.
- W2945914965 hasConceptScore W2945914965C49039625 @default.
- W2945914965 hasConceptScore W2945914965C55493867 @default.
- W2945914965 hasConceptScore W2945914965C555293320 @default.
- W2945914965 hasConceptScore W2945914965C71315377 @default.
- W2945914965 hasConceptScore W2945914965C71924100 @default.
- W2945914965 hasConceptScore W2945914965C86803240 @default.
- W2945914965 hasLocation W29459149651 @default.
- W2945914965 hasOpenAccess W2945914965 @default.
- W2945914965 hasPrimaryLocation W29459149651 @default.
- W2945914965 hasRelatedWork W1972398506 @default.
- W2945914965 hasRelatedWork W1992189503 @default.
- W2945914965 hasRelatedWork W2009164222 @default.
- W2945914965 hasRelatedWork W2013082477 @default.
- W2945914965 hasRelatedWork W2033079365 @default.
- W2945914965 hasRelatedWork W2057702387 @default.
- W2945914965 hasRelatedWork W2089731474 @default.
- W2945914965 hasRelatedWork W2133162113 @default.
- W2945914965 hasRelatedWork W2152880048 @default.
- W2945914965 hasRelatedWork W2159055604 @default.
- W2945914965 hasRelatedWork W2540425834 @default.
- W2945914965 hasRelatedWork W2756057189 @default.
- W2945914965 hasRelatedWork W3009862144 @default.
- W2945914965 hasRelatedWork W3097446545 @default.
- W2945914965 hasRelatedWork W3110953369 @default.
- W2945914965 hasRelatedWork W3149186016 @default.
- W2945914965 isParatext "false" @default.
- W2945914965 isRetracted "false" @default.
- W2945914965 magId "2945914965" @default.
- W2945914965 workType "dissertation" @default.