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- W2945934429 endingPage "11360" @default.
- W2945934429 startingPage "11351" @default.
- W2945934429 abstract "Historically, the evolution of bats has been analyzed using a small number of genetic loci for many species or many genetic loci for a few species. Here we present a phylogeny of 18 bat species, each of which is represented in 1,107 orthologous gene alignments used to build the tree. We generated a transcriptome sequence of Hypsignathus monstrosus, the African hammer-headed bat, and additional transcriptome sequence for Rousettus aegyptiacus, the Egyptian fruit bat. We then combined these data with existing genomic and transcriptomic data from 16 other bat species. In the analysis of such datasets, there is no clear consensus on the most reliable computational methods for the curation of quality multiple sequence alignments since these public datasets represent multiple investigators and methods, including different source materials (chromosomal DNA or expressed RNA). Here we lay out a systematic analysis of parameters and produce an advanced pipeline for curating orthologous gene alignments from combined transcriptomic and genomic data, including a software package: the Mismatching Isoform eXon Remover (MIXR). Using this method, we created alignments of 11,677 bat genes, 1,107 of which contain orthologs from all 18 species. Using the orthologous gene alignments created, we assessed bat phylogeny and also performed a holistic analysis of positive selection acting in bat genomes. We found that 181 genes have been subject to positive natural selection. This list is dominated by genes involved in immune responses and genes involved in the production of collagens." @default.
- W2945934429 created "2019-05-29" @default.
- W2945934429 creator A5011461272 @default.
- W2945934429 creator A5012500396 @default.
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- W2945934429 creator A5031023990 @default.
- W2945934429 creator A5041846756 @default.
- W2945934429 creator A5070782543 @default.
- W2945934429 date "2019-05-21" @default.
- W2945934429 modified "2023-10-14" @default.
- W2945934429 title "A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species" @default.
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