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• W2945935952 abstract "This study aimed to (1) investigate the effect of GJB2 and SLC26A4 gene mutations on auditory nerve function in pediatric cochlear implant users and (2) compare their results with those measured in implanted children with idiopathic hearing loss.Participants included 20 children with biallelic GJB2 mutations, 16 children with biallelic SLC26A4 mutations, and 19 children with idiopathic hearing loss. All subjects except for two in the SLC26A4 group had concurrent Mondini malformation and enlarged vestibular aqueduct. All subjects used Cochlear Nucleus devices in their test ears. For each subject, electrophysiological measures of the electrically evoked compound action potential (eCAP) were recorded using both anodic- and cathodic-leading biphasic pulses. Dependent variables (DVs) of interest included slope of eCAP input/output (I/O) function, the eCAP threshold, and eCAP amplitude measured at the maximum comfortable level (C level) of the anodic-leading stimulus (i.e., the anodic C level). Slopes of eCAP I/O functions were estimated using statistical modeling with a linear regression function. These DVs were measured at three electrode locations across the electrode array. Generalized linear mixed effect models were used to evaluate the effects of study group, stimulus polarity, and electrode location on each DV.Steeper slopes of eCAP I/O function, lower eCAP thresholds, and larger eCAP amplitude at the anodic C level were measured for the anodic-leading stimulus compared with the cathodic-leading stimulus in all subject groups. Children with GJB2 mutations showed steeper slopes of eCAP I/O function and larger eCAP amplitudes at the anodic C level than children with SLC26A4 mutations and children with idiopathic hearing loss for both the anodic- and cathodic-leading stimuli. In addition, children with GJB2 mutations showed a smaller increase in eCAP amplitude when the stimulus changed from the cathodic-leading pulse to the anodic-leading pulse (i.e., smaller polarity effect) than children with idiopathic hearing loss. There was no statistically significant difference in slope of eCAP I/O function, eCAP amplitude at the anodic C level, or the size of polarity effect on all three DVs between children with SLC26A4 mutations and children with idiopathic hearing loss. These results suggested that better auditory nerve function was associated with GJB2 but not with SLC26A4 mutations when compared with idiopathic hearing loss. In addition, significant effects of electrode location were observed for slope of eCAP I/O function and the eCAP threshold.GJB2 and SLC26A4 gene mutations did not alter polarity sensitivity of auditory nerve fibers to electrical stimulation. The anodic-leading stimulus was generally more effective in activating auditory nerve fibers than the cathodic-leading stimulus, despite the presence of GJB2 or SLC26A4 mutations. Patients with GJB2 mutations appeared to have better functional status of the auditory nerve than patients with SLC26A4 mutations who had concurrent Mondini malformation and enlarged vestibular aqueduct and patients with idiopathic hearing loss." @default.
• W2945935952 created "2019-05-29" @default.
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• W2945935952 date "2019-05-20" @default.
• W2945935952 modified "2023-10-18" @default.
• W2945935952 title "The Effects of GJB2 or SLC26A4 Gene Mutations on Neural Response of the Electrically Stimulated Auditory Nerve in Children" @default.
• W2945935952 cites W1004733539 @default.
• W2945935952 cites W1480384350 @default.
• W2945935952 cites W1487490912 @default.
• W2945935952 cites W1919344005 @default.
• W2945935952 cites W1967829341 @default.
• W2945935952 cites W1973593620 @default.
• W2945935952 cites W1975679932 @default.
• W2945935952 cites W1979555369 @default.
• W2945935952 cites W1979894154 @default.
• W2945935952 cites W1985512068 @default.
• W2945935952 cites W1987074345 @default.
• W2945935952 cites W1989854430 @default.
• W2945935952 cites W1991626429 @default.
• W2945935952 cites W1991857211 @default.
• W2945935952 cites W1992453879 @default.
• W2945935952 cites W1992943506 @default.
• W2945935952 cites W1994193401 @default.
• W2945935952 cites W1996569612 @default.
• W2945935952 cites W2009133456 @default.
• W2945935952 cites W2010320232 @default.
• W2945935952 cites W2010380724 @default.
• W2945935952 cites W2012189865 @default.
• W2945935952 cites W2012189889 @default.
• W2945935952 cites W2013506837 @default.
• W2945935952 cites W2017209077 @default.
• W2945935952 cites W2018075727 @default.
• W2945935952 cites W2020052080 @default.
• W2945935952 cites W2023613810 @default.
• W2945935952 cites W2023617921 @default.
• W2945935952 cites W2027060549 @default.
• W2945935952 cites W2029973746 @default.
• W2945935952 cites W2034331964 @default.
• W2945935952 cites W2036645640 @default.
• W2945935952 cites W2039224372 @default.
• W2945935952 cites W2040725120 @default.
• W2945935952 cites W2043511649 @default.
• W2945935952 cites W2045029762 @default.
• W2945935952 cites W2049828107 @default.
• W2945935952 cites W2050572810 @default.
• W2945935952 cites W2051085824 @default.
• W2945935952 cites W2057880512 @default.
• W2945935952 cites W2058561004 @default.
• W2945935952 cites W2073557209 @default.
• W2945935952 cites W2073745831 @default.
• W2945935952 cites W2079693572 @default.
• W2945935952 cites W2080097561 @default.
• W2945935952 cites W2082610294 @default.
• W2945935952 cites W2083945317 @default.
• W2945935952 cites W2088035774 @default.
• W2945935952 cites W2090742630 @default.
• W2945935952 cites W2091550421 @default.
• W2945935952 cites W2101494298 @default.
• W2945935952 cites W2102326129 @default.
• W2945935952 cites W2114309709 @default.
• W2945935952 cites W2118347619 @default.
• W2945935952 cites W2118652583 @default.
• W2945935952 cites W2124892679 @default.
• W2945935952 cites W2127330929 @default.
• W2945935952 cites W2132008997 @default.
• W2945935952 cites W2166542457 @default.
• W2945935952 cites W2168274033 @default.
• W2945935952 cites W2171073672 @default.
• W2945935952 cites W2307142296 @default.
• W2945935952 cites W2324022817 @default.
• W2945935952 cites W2335616861 @default.
• W2945935952 cites W2338153344 @default.
• W2945935952 cites W2501653911 @default.
• W2945935952 cites W2531436018 @default.
• W2945935952 cites W2560898956 @default.
• W2945935952 cites W2582036620 @default.
• W2945935952 cites W2587791423 @default.
• W2945935952 cites W2597844745 @default.
• W2945935952 cites W2605857958 @default.
• W2945935952 cites W2723361935 @default.
• W2945935952 cites W2726847069 @default.
• W2945935952 cites W2745114912 @default.
• W2945935952 cites W2745169247 @default.
• W2945935952 cites W2755619166 @default.
• W2945935952 cites W2780669896 @default.
• W2945935952 cites W2795668475 @default.
• W2945935952 cites W2900372861 @default.
• W2945935952 doi "https://doi.org/10.1097/aud.0000000000000744" @default.
• W2945935952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31124793" @default.
• W2945935952 hasPublicationYear "2019" @default.

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