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- W2945940549 abstract "Abstract Recent study has reported that microRNA‐628‐5p (miR‐628‐5p) is involved in the development of epithelial ovarian cancer; however, the mechanisms of miR‐628‐5p in glioma remain unclear. In this study, we explored the potential biological roles of miR‐628‐5p in glioma. First, we found that miR‐628‐5p was decreased in the tissues and cells (U87 and T98) of glioma. Second, overexpressing miR‐628‐5p reduced the ability of glioma cells' proliferation and induced glioma cells' cycle arrest in G1. Then, we found that miR‐628‐5p directly bound to the 3′‐untranslated region of DDX59 and decreased the protein level of DDX59. The decrease of DDX59 was found to lead to the decrease of p‐AKT. Mechanistic studies revealed that restoring the expression of DDX59 alleviated miR‐628‐5p‐induced inhibition of proliferation of glioma. These findings suggest that the miR‐628‐5p/DDX59 axis has a key role in the development of glioma, and miR‐628‐5p might be a new therapeutic target against glioma." @default.
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- W2945940549 date "2019-05-20" @default.
- W2945940549 modified "2023-10-17" @default.
- W2945940549 title "MicroRNA‐628‐5p inhibits cell proliferation in glioma by targeting DDX59" @default.
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- W2945940549 doi "https://doi.org/10.1002/jcb.28991" @default.
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