FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945948358> ?p ?o ?g. }

• W2945948358 endingPage "e78" @default.
• W2945948358 startingPage "e66" @default.
• W2945948358 abstract "Aim: The aims of this study were to assess survival outcome of pediatric patients with localized osteosarcoma of the extremities in Upper Egypt, identify factors of prognostic significance for survival, and to determine factors predictive of surgical methods used in these patients, as well as developing a clinical model for risk prediction. Patients and Methods: A retrospective analysis of data assembled from medical records of 30 pediatric patients with a histologically verified nonmetastatic osteosarcoma of the extremities treated at South Egypt Cancer Institute with a unified chemotherapy protocol between January 2001 and December 2015 was carried out. Prognostic factors were determined using univariable and multivariable methods. A model for surgical outcomes in these patients based on the baseline clinical factors, and the parameters predictive of their tumor response to chemotherapy, was developed. Results: With a median follow-up of 63 months for the study population, the estimates for event-free survival and overall survival (OS) at 3 and 5 years were 69.5% and 79% and 65.2% and 65.3%, respectively. Age 16 years or above was independently associated with both worse metastasis-free survival (hazard ratio [HR]=6.05, 95% confidence interval [CI]: 1.43-25.6, P =0.015) and OS (HR=7.9, 95% CI: 1.71-36.2, P =0.008). In the multivariable analysis, a proximal location within the limb gained a statistical significance to be independently associated with worse OS (HR=2.4, 95% CI: 1.13-22.1, P =0.003). Poor response to chemotherapy was marginally associated with worse metastasis-free survival (HR=4.9, 95% CI: 1.02-23.8, P =0.047) only in the univariable analysis. The patients found to be more likely to undergo an amputation surgery (odds ratio=14.1, 95% CI: 1.34-149.4, P =0.028) were those in whom a tumor was poorly responding to chemotherapy. Conclusion: In Upper Egypt, despite the reasonable survival outcomes in nonmetastatic osteosarcoma, a relatively high limb amputation rate has been encountered. The development of a clinical prediction model for future planning of possible outcome improvement in these patients, however, is still feasible." @default.
• W2945948358 created "2019-05-29" @default.
• W2945948358 creator A5006904016 @default.
• W2945948358 creator A5017885340 @default.
• W2945948358 creator A5028294033 @default.
• W2945948358 creator A5030678596 @default.
• W2945948358 creator A5042640895 @default.
• W2945948358 creator A5050690280 @default.
• W2945948358 creator A5063477957 @default.
• W2945948358 creator A5068540742 @default.
• W2945948358 date "2020-03-01" @default.
• W2945948358 modified "2023-09-27" @default.
• W2945948358 title "Age and Tumor Location Predict Survival in Nonmetastatic Osteosarcoma in Upper Egypt" @default.
• W2945948358 cites W112362463 @default.
• W2945948358 cites W1514489797 @default.
• W2945948358 cites W1519570912 @default.
• W2945948358 cites W1744787733 @default.
• W2945948358 cites W1846976861 @default.
• W2945948358 cites W1925764013 @default.
• W2945948358 cites W1960585793 @default.
• W2945948358 cites W1971063058 @default.
• W2945948358 cites W1971290708 @default.
• W2945948358 cites W1974907966 @default.
• W2945948358 cites W1977213744 @default.
• W2945948358 cites W1977868390 @default.
• W2945948358 cites W1985147842 @default.
• W2945948358 cites W1986871224 @default.
• W2945948358 cites W1988325237 @default.
• W2945948358 cites W1991397916 @default.
• W2945948358 cites W1991401391 @default.
• W2945948358 cites W1994525377 @default.
• W2945948358 cites W1994682257 @default.
• W2945948358 cites W1995150074 @default.
• W2945948358 cites W1999901442 @default.
• W2945948358 cites W2002622600 @default.
• W2945948358 cites W2009430421 @default.
• W2945948358 cites W2013881151 @default.
• W2945948358 cites W2014305454 @default.
• W2945948358 cites W2017454339 @default.
• W2945948358 cites W2017967092 @default.
• W2945948358 cites W2023208421 @default.
• W2945948358 cites W2023321256 @default.
• W2945948358 cites W2025557852 @default.
• W2945948358 cites W2028948780 @default.
• W2945948358 cites W2031334096 @default.
• W2945948358 cites W2034741183 @default.
• W2945948358 cites W2036193982 @default.
• W2945948358 cites W2040383294 @default.
• W2945948358 cites W2043003346 @default.
• W2945948358 cites W2048091664 @default.
• W2945948358 cites W2050592402 @default.
• W2945948358 cites W2052299135 @default.
• W2945948358 cites W2053774591 @default.
• W2945948358 cites W2058245259 @default.
• W2945948358 cites W2062687868 @default.
• W2945948358 cites W2063282481 @default.
• W2945948358 cites W2065289547 @default.
• W2945948358 cites W2070245805 @default.
• W2945948358 cites W2073071263 @default.
• W2945948358 cites W2077648114 @default.
• W2945948358 cites W2083025098 @default.
• W2945948358 cites W2084270660 @default.
• W2945948358 cites W2085276166 @default.
• W2945948358 cites W2085372949 @default.
• W2945948358 cites W2095657951 @default.
• W2945948358 cites W2096748119 @default.
• W2945948358 cites W2098002569 @default.
• W2945948358 cites W2100055648 @default.
• W2945948358 cites W2110022678 @default.
• W2945948358 cites W2110961680 @default.
• W2945948358 cites W2111727585 @default.
• W2945948358 cites W2113340825 @default.
• W2945948358 cites W2115715988 @default.
• W2945948358 cites W2122390343 @default.
• W2945948358 cites W2122532950 @default.
• W2945948358 cites W2130373985 @default.
• W2945948358 cites W2130383002 @default.
• W2945948358 cites W2136399690 @default.
• W2945948358 cites W2139619092 @default.
• W2945948358 cites W2140700546 @default.
• W2945948358 cites W2142286699 @default.
• W2945948358 cites W2146094182 @default.
• W2945948358 cites W2146426575 @default.
• W2945948358 cites W2156460327 @default.
• W2945948358 cites W2159385623 @default.
• W2945948358 cites W2160309286 @default.
• W2945948358 cites W2161136893 @default.
• W2945948358 cites W2164614740 @default.
• W2945948358 cites W2165678358 @default.
• W2945948358 cites W2167122694 @default.
• W2945948358 cites W2170636410 @default.
• W2945948358 cites W2171865378 @default.
• W2945948358 cites W2198846739 @default.
• W2945948358 cites W2279538354 @default.
• W2945948358 cites W2292595061 @default.
• W2945948358 cites W2323464821 @default.
• W2945948358 cites W2327625380 @default.
• W2945948358 cites W2329218644 @default.

• next