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- W2945954503 abstract "Induction of lysosomal exocytosis alleviates lysosomal storage of undigested metabolites in cell models of lysosomal disorders (LDs). However, whether this strategy affects other vesicular compartments, e.g., those involved in endocytosis, is unknown. This is important both to predict side effects and to use this strategy in combination with therapies that require endocytosis for intracellular delivery, such as lysosomal enzyme replacement therapy (ERT). We investigated this using δ-tocopherol as a model previously shown to induce lysosomal exocytosis and cell models of type A Niemann-Pick disease, a LD characterized by acid sphingomyelinase (ASM) deficiency and sphingomyelin storage. δ-Tocopherol and derivative CF3-T reduced net accumulation of fluid phase, ligands, and polymer particles via phagocytic, caveolae-, clathrin-, and cell adhesion molecule (CAM)-mediated pathways, yet the latter route was less affected due to receptor overexpression. In agreement, δ-tocopherol lowered uptake of recombinant ASM by deficient cells (known to occur via the clathrin pathway) and via targeting intercellular adhesion molecule-1 (associated to the CAM pathway). However, the net enzyme activity delivered and lysosomal storage attenuation were greater via the latter route. Data suggest stimulation of exocytosis by tocopherols is not specific of lysosomes and affects endocytic cargo. However, this effect was transient and became unnoticeable several hours after tocopherol removal. Therefore, induction of exocytosis in combination with therapies requiring endocytic uptake, such as ERT, may represent a new type of drug interaction, yet this strategy could be valuable if properly timed for minimal interference." @default.
- W2945954503 created "2019-05-29" @default.
- W2945954503 creator A5000819682 @default.
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- W2945954503 creator A5070739043 @default.
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- W2945954503 creator A5089100097 @default.
- W2945954503 date "2019-05-17" @default.
- W2945954503 modified "2023-10-09" @default.
- W2945954503 title "<i>δ</i>-Tocopherol Effect on Endocytosis and Its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: A New Type of Drug Interaction?" @default.
- W2945954503 cites W1480300079 @default.
- W2945954503 cites W1515444383 @default.
- W2945954503 cites W1573311361 @default.
- W2945954503 cites W1821428314 @default.
- W2945954503 cites W1932105136 @default.
- W2945954503 cites W1964712521 @default.
- W2945954503 cites W1975842277 @default.
- W2945954503 cites W1984841297 @default.
- W2945954503 cites W1987054071 @default.
- W2945954503 cites W1987780432 @default.
- W2945954503 cites W1989297470 @default.
- W2945954503 cites W1994519378 @default.
- W2945954503 cites W1997861265 @default.
- W2945954503 cites W1998249296 @default.
- W2945954503 cites W2001921621 @default.
- W2945954503 cites W2003003181 @default.
- W2945954503 cites W2008365765 @default.
- W2945954503 cites W2014904984 @default.
- W2945954503 cites W2015497529 @default.
- W2945954503 cites W2016550339 @default.
- W2945954503 cites W2016740239 @default.
- W2945954503 cites W2017593971 @default.
- W2945954503 cites W2017779665 @default.
- W2945954503 cites W2021565098 @default.
- W2945954503 cites W2023863818 @default.
- W2945954503 cites W2024292300 @default.
- W2945954503 cites W2027205611 @default.
- W2945954503 cites W2028038439 @default.
- W2945954503 cites W2034017705 @default.
- W2945954503 cites W2035839114 @default.
- W2945954503 cites W2039187058 @default.
- W2945954503 cites W2040503264 @default.
- W2945954503 cites W2047532620 @default.
- W2945954503 cites W2049914201 @default.
- W2945954503 cites W2050063403 @default.
- W2945954503 cites W2056194352 @default.
- W2945954503 cites W2057132744 @default.
- W2945954503 cites W2061965725 @default.
- W2945954503 cites W2067102002 @default.
- W2945954503 cites W2076107153 @default.
- W2945954503 cites W2077850064 @default.
- W2945954503 cites W2082143317 @default.
- W2945954503 cites W2088464114 @default.
- W2945954503 cites W2092201159 @default.
- W2945954503 cites W2092282071 @default.
- W2945954503 cites W2094399039 @default.
- W2945954503 cites W2095507242 @default.
- W2945954503 cites W2109057110 @default.
- W2945954503 cites W2113698463 @default.
- W2945954503 cites W2114277918 @default.
- W2945954503 cites W2114494901 @default.
- W2945954503 cites W2114899816 @default.
- W2945954503 cites W2115999846 @default.
- W2945954503 cites W2116691006 @default.
- W2945954503 cites W2119476922 @default.
- W2945954503 cites W2120788536 @default.
- W2945954503 cites W2131614257 @default.
- W2945954503 cites W2131745475 @default.
- W2945954503 cites W2134344512 @default.
- W2945954503 cites W2139826283 @default.
- W2945954503 cites W2141322398 @default.
- W2945954503 cites W2141890696 @default.
- W2945954503 cites W2143310572 @default.
- W2945954503 cites W2153824991 @default.
- W2945954503 cites W2155777849 @default.
- W2945954503 cites W2156779401 @default.
- W2945954503 cites W2157973824 @default.
- W2945954503 cites W2158058189 @default.
- W2945954503 cites W2161841050 @default.
- W2945954503 cites W2167806590 @default.
- W2945954503 cites W2239468677 @default.
- W2945954503 cites W2323243994 @default.
- W2945954503 cites W2408760616 @default.
- W2945954503 cites W2408805966 @default.
- W2945954503 cites W2503813346 @default.
- W2945954503 cites W2513167391 @default.
- W2945954503 cites W2524344101 @default.
- W2945954503 cites W2562918265 @default.
- W2945954503 cites W2613454210 @default.
- W2945954503 cites W2618738661 @default.
- W2945954503 cites W2884858478 @default.
- W2945954503 cites W2921660565 @default.
- W2945954503 cites W4301208235 @default.