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- W2945971202 abstract "A cure for type 1 diabetes (T1D) would help millions of people worldwide, but remains elusive thus far. Tolerogenic vaccines and beta cell replacement therapy are complementary therapies that seek to address aberrant T1D autoimmune attack and subsequent beta cell loss. However, both approaches require some form of systematic immunosuppression, imparting risks to the patient. Biomaterials-based tools enable localized and targeted immunomodulation, and biomaterial properties can be designed and combined with immunomodulatory agents to locally instruct specific immune responses. In this Review, we discuss immunomodulatory biomaterial platforms for the development of T1D tolerogenic vaccines and beta cell replacement devices. We investigate nano- and microparticles for the delivery of tolerogenic agents and autoantigens, and as artificial antigen presenting cells, and highlight how bulk biomaterials can be used to provide immune tolerance. We examine biomaterials for drug delivery and as immunoisolation devices for cell therapy and islet transplantation, and explore synergies with other fields for the development of new T1D treatment strategies." @default.
- W2945971202 created "2019-05-29" @default.
- W2945971202 creator A5002728901 @default.
- W2945971202 creator A5050560456 @default.
- W2945971202 creator A5055749290 @default.
- W2945971202 creator A5087887791 @default.
- W2945971202 date "2019-05-17" @default.
- W2945971202 modified "2023-10-14" @default.
- W2945971202 title "Engineering immunomodulatory biomaterials for type 1 diabetes" @default.
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