Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945972003> ?p ?o ?g. }
- W2945972003 endingPage "1898" @default.
- W2945972003 startingPage "1898" @default.
- W2945972003 abstract "(1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasma concentrations at different time points, and DAS software was used to calculate pharmacokinetic parameters in a noncompartmental model. (3) Results: The results showed that the pharmacodynamics and pharmacokinetics of one of the five anthraquinone aglycones could be modified by the other four anthraquinones, and the degree of interaction between different anthraquinones was different. The chrysophanol group showed the greatest reduction in pharmacodynamic indicators comparing with other four groups where the rats were administered one of the five anthraquinones, and there was no significant difference between the nimodipine group. While the Aloe-emodin + Physcion group showed the most obvious anti-ischemic effect among the groups where the subjects were administered two of the five anthraquinones simultaneously. Emodin, rhein, chrysophanol, and physcion all increase plasma exposure levels of aloe-emodin, while aloe-emodin lower their plasma exposure levels. (4) Conclusions: This experiment provides a certain preclinical basis for the study of anthraquinone aglycones against cerebral ischemia and a theoretical basis for the study of the mechanism of interaction between anthraquinones." @default.
- W2945972003 created "2019-05-29" @default.
- W2945972003 creator A5000503520 @default.
- W2945972003 creator A5005477512 @default.
- W2945972003 creator A5006465461 @default.
- W2945972003 creator A5015741830 @default.
- W2945972003 creator A5025855204 @default.
- W2945972003 creator A5038497095 @default.
- W2945972003 creator A5042467158 @default.
- W2945972003 creator A5081479675 @default.
- W2945972003 date "2019-05-17" @default.
- W2945972003 modified "2023-10-18" @default.
- W2945972003 title "Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia" @default.
- W2945972003 cites W1559230540 @default.
- W2945972003 cites W1869962776 @default.
- W2945972003 cites W1963920115 @default.
- W2945972003 cites W1976272464 @default.
- W2945972003 cites W1980621373 @default.
- W2945972003 cites W1998437958 @default.
- W2945972003 cites W2009287108 @default.
- W2945972003 cites W2009972157 @default.
- W2945972003 cites W2016212019 @default.
- W2945972003 cites W2024419054 @default.
- W2945972003 cites W2038666492 @default.
- W2945972003 cites W2050735942 @default.
- W2945972003 cites W2080608505 @default.
- W2945972003 cites W2108616612 @default.
- W2945972003 cites W2112565294 @default.
- W2945972003 cites W2123991024 @default.
- W2945972003 cites W2153506838 @default.
- W2945972003 cites W2155337367 @default.
- W2945972003 cites W2256863271 @default.
- W2945972003 cites W2299370541 @default.
- W2945972003 cites W2342380428 @default.
- W2945972003 cites W2408313511 @default.
- W2945972003 cites W2410210442 @default.
- W2945972003 cites W2410671496 @default.
- W2945972003 cites W2529554065 @default.
- W2945972003 cites W2586626701 @default.
- W2945972003 cites W2734950587 @default.
- W2945972003 cites W2751369801 @default.
- W2945972003 cites W2761459420 @default.
- W2945972003 cites W2789293914 @default.
- W2945972003 cites W2792377060 @default.
- W2945972003 cites W2810447510 @default.
- W2945972003 cites W2883834775 @default.
- W2945972003 cites W2883966280 @default.
- W2945972003 cites W2888512490 @default.
- W2945972003 cites W3167945921 @default.
- W2945972003 doi "https://doi.org/10.3390/molecules24101898" @default.
- W2945972003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6571683" @default.
- W2945972003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31108858" @default.
- W2945972003 hasPublicationYear "2019" @default.
- W2945972003 type Work @default.
- W2945972003 sameAs 2945972003 @default.
- W2945972003 citedByCount "31" @default.
- W2945972003 countsByYear W29459720032020 @default.
- W2945972003 countsByYear W29459720032021 @default.
- W2945972003 countsByYear W29459720032022 @default.
- W2945972003 countsByYear W29459720032023 @default.
- W2945972003 crossrefType "journal-article" @default.
- W2945972003 hasAuthorship W2945972003A5000503520 @default.
- W2945972003 hasAuthorship W2945972003A5005477512 @default.
- W2945972003 hasAuthorship W2945972003A5006465461 @default.
- W2945972003 hasAuthorship W2945972003A5015741830 @default.
- W2945972003 hasAuthorship W2945972003A5025855204 @default.
- W2945972003 hasAuthorship W2945972003A5038497095 @default.
- W2945972003 hasAuthorship W2945972003A5042467158 @default.
- W2945972003 hasAuthorship W2945972003A5081479675 @default.
- W2945972003 hasBestOaLocation W29459720031 @default.
- W2945972003 hasConcept C111113717 @default.
- W2945972003 hasConcept C112705442 @default.
- W2945972003 hasConcept C126322002 @default.
- W2945972003 hasConcept C178790620 @default.
- W2945972003 hasConcept C185592680 @default.
- W2945972003 hasConcept C2777294900 @default.
- W2945972003 hasConcept C2777412654 @default.
- W2945972003 hasConcept C2778248515 @default.
- W2945972003 hasConcept C2778913731 @default.
- W2945972003 hasConcept C2779450755 @default.
- W2945972003 hasConcept C2780867653 @default.
- W2945972003 hasConcept C43617362 @default.
- W2945972003 hasConcept C519063684 @default.
- W2945972003 hasConcept C541997718 @default.
- W2945972003 hasConcept C59822182 @default.
- W2945972003 hasConcept C71924100 @default.
- W2945972003 hasConcept C86803240 @default.
- W2945972003 hasConcept C98274493 @default.
- W2945972003 hasConceptScore W2945972003C111113717 @default.
- W2945972003 hasConceptScore W2945972003C112705442 @default.
- W2945972003 hasConceptScore W2945972003C126322002 @default.
- W2945972003 hasConceptScore W2945972003C178790620 @default.
- W2945972003 hasConceptScore W2945972003C185592680 @default.
- W2945972003 hasConceptScore W2945972003C2777294900 @default.
- W2945972003 hasConceptScore W2945972003C2777412654 @default.
- W2945972003 hasConceptScore W2945972003C2778248515 @default.
- W2945972003 hasConceptScore W2945972003C2778913731 @default.
- W2945972003 hasConceptScore W2945972003C2779450755 @default.