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- W2945976721 abstract "Aim: To quantitatively investigate the brain structure of patients withfibromyalgia (FMS) using MRI and the advanced analytical technique ofStatistical Parametric Mapping (SPM).Methods: 30 women with primary FMS, 9 taking no medications, and 29age- and gender-matched healthy controls underwent 1.5 Tesla T1- andT2-weighted MRI brain scans comprising 4-mm trans-axial slices. All had ablinded manual tender point examination and completed standard clinicalvariablequestionnaires (FIQ, MPQ, STAI, CES-D). Using the SPM99 andSPM2 software packages, all MRI images were transformed to a standardanatomical space, scaled and subjected to voxel-by-voxel statistics. Voxelswith uncorrected P < 0.001 were thereby identified.Results: Regression analysis of T2 scans revealed increased signal(corrected cluster P = 0.031) in the posterior orbito-frontal regions in FMSversus control subjects, adjusted for age. Regression of T2 scans within theFMS group alone detected with increasing pain duration (0.5–45 years) awidespread patchy increase in white matter signal, significant in the dorsalright insula (corrected cluster P = 0.001) and right dorsal prefrontal lobe(corrected cluster P = 0.028) adjusted for age, and with increasing physicalimpairment last week a reduction in medial posterior cerebellar signal(corrected cluster P < 0.0005) adjusted for age. No relationship with anyother clinical variable was detected, including psychological and drugusage.Conclusions: Our results suggest that sub-visual cerebral structuralchanges occur in FMS unrelated to psychological distress and medications,and may provide a patho-anatomical basis for its associated cold allodyniaand impaired working memory" @default.
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- W2945976721 date "2004-01-01" @default.
- W2945976721 modified "2023-09-23" @default.
- W2945976721 title "MRI evidence of sub-visual changes in brain structure in fibromyalgia" @default.
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