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- W2945985753 abstract "The relationship between Ca2+ ion and factor X-activator of Russell’s-viper-venom (RVV) seems to point to some sort of stoichiometry as evidenced from the composition and stability studies using an approximate concept of the Job’s method of continuous variation. The concept of the method, used in co-ordination chemistry to ascertain the metal-ligand interacting ratio has been used, in order to interpret the results. The clotting time was measured by varying Ca2+ ion and venom concentrations respectively and ‘log of clotting time’ was plotted against concentration in each case, and the minimum in the curve was taken to represent the maximum formation of the complex of Ca2+ ion with factor X-activator of RW. The plot of clotting time against the ratios of venom and Ca2+ ion concentrations also pointed to an interacting ratio. At higher concentrations either of Caion or of venom, longer clotting time points respectively to the salt-effect and the denaturising effect of the venom on plasma-proteins. Accordingly it is concluded that Ca2+ ion activates the factor X-activator in definite ratio before the activated metal-enzyme complex (M-E), acts on its substrate to produce E-M-S or E<SM for the formation of the products." @default.
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- W2945985753 date "1977-01-01" @default.
- W2945985753 modified "2023-09-27" @default.
- W2945985753 title "On the Activation of Factor X-Activator of the Russell’s Viper-Venom by Calcium" @default.
- W2945985753 doi "https://doi.org/10.1055/s-0039-1682459" @default.
- W2945985753 hasPublicationYear "1977" @default.
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