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- W2945986243 abstract "The ataxia telangiectasia and Rad3-related (ATR) checkpoint kinase 1 (CHK1) pathway plays an essential role in suppressing replication stress from DNA damage and oncogene activation. Preclinical studies have shown that cancer cells with defective DNA repair mechanisms or cell cycle checkpoints may be particularly sensitive to ATR inhibitors. Preclinical and clinical data from early-phase trials on three ATR inhibitors (M6620, AZD6738, and BAY1895344), either as monotherapy or in combination, were reviewed. Data from ATR inhibitor-based combinational trials might lead to future expansion of this therapy to homologous recombination repair pathway-proficient cancers and potentially serve as a rescue therapy for patients who have progressed through poly ADP-ribose polymerase inhibitors." @default.
- W2945986243 created "2019-05-29" @default.
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- W2945986243 date "2019-04-24" @default.
- W2945986243 modified "2023-10-18" @default.
- W2945986243 title "Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand" @default.
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- W2945986243 doi "https://doi.org/10.1186/s13045-019-0733-6" @default.
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