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- W2946004042 abstract "Background: Ketamine as a dissociative agent can induce dreaming and hallucinations during revival, which have limited its use in adults. The co-administration of midazolam, however, has been clearly shown to attenuate the perceptual abnormalities and thought disorders induced by ketamine. Objective: The aim of this study was to evaluate the latency interval effect midazolam and ketamine on post-anesthetic delirium after minor gynecologic surgeries. Methods: A randomized parallel double blinded clinical trial. The study was conducted from September 2015 to March 2016. A total of 100 women undergoing minor gynecological surgeries were randomized into 4 groups. The median age of the patients was 31.08 +/- 8.99. In this trial, the groups were defined according to the time intervals of 0, 2.5, 5, and 7.5 minutes between the administration of midazolam (0.05 mg/kg) and ketamine (1.5 mg/kg). Delirium was measured by the degree of comfort, speech impediment, and delirium level. The data were analyzed in SPSS software by chi square and t tests. Our primary endpoint was the extent of midazolam's administration time lag effect on ketamine's post anesthetic delirium level. Results: The incidence of delirium in all participants according to degree of comfort or tranquility, speech impediment, and delirium were 6%, 17%, and 22%, respectively. The comparison among groups showed no significant difference between the time interval of injections and the degree of tranquility and speech impediment, while the time interval and degree of delirium showed significant differences between group 1 and 3, group 2 and 3, and group 2 and 4. An increased time interval between administration of drugs to 5 minutes meaningfully decreased the delirium level but a latency interval of greater than or less than 5 minutes did not show any significant effects on delirium. Conclusion: According to our findings, it is better to administer midazolam 5 minutes before ketamine in order to effectively decrease the incidence of delirium." @default.
- W2946004042 created "2019-05-29" @default.
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- W2946004042 date "2018-01-01" @default.
- W2946004042 modified "2023-09-27" @default.
- W2946004042 title "Effect of the time interval between administering midazolam and ketamine on delirium after gynecologic surgeries:A randomized parallel clinical trial" @default.
- W2946004042 hasPublicationYear "2018" @default.
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