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• W2946008902 endingPage "2447" @default.
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• W2946008902 abstract "The cloning, purification, and initial characterization of the β-carbonic anhydrase (CA, EC 4.2.1.1) from the genome of the opportunistic pathogen Malassezia restricta (MreCA), which a fungus involved in dandruff and seborrheic dermatitis (SD), is reported. MreCA is a protein consisting of 230 amino acid residues and shows high catalytic activity for the hydration of CO2 into bicarbonate and protons, with the following kinetic parameters: kcat of 1.06 × 106 s−1 and kcat/KM of 1.07 × 108 M−1 s−1. It is also sensitive to inhibition by the sulfonamide acetazolamide (KI of 50.7 nM). Phylogenetically, MreCA and other CAs from various Malassezia species seem to be on a different branch, distinct from that of other β-CAs found in fungi, such as Candida spp., Saccharomyces cerevisiae, Aspergillus fumigatus, and Sordaria macrospora, with only Cryptococcus neoformans and Ustilago maydis enzymes clustering near MreCA. The further characterization of this enzyme and the identification of inhibitors that may interfere with its life cycle might constitute new strategies for fighting dandruff and SD." @default.
• W2946008902 created "2019-05-29" @default.
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• W2946008902 date "2019-05-17" @default.
• W2946008902 modified "2023-10-01" @default.
• W2946008902 title "Cloning, Purification, and Characterization of a β-Carbonic Anhydrase from Malassezia restricta, an Opportunistic Pathogen Involved in Dandruff and Seborrheic Dermatitis" @default.
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• W2946008902 doi "https://doi.org/10.3390/ijms20102447" @default.
• W2946008902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6566260" @default.
• W2946008902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31108925" @default.
• W2946008902 hasPublicationYear "2019" @default.
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