Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946018920> ?p ?o ?g. }
- W2946018920 abstract "The progress of treatments of childhood acute lymphoblastic leukemia (ALL) has made it possible to reach a survival rate superior to 80%. However, the treatments lead to several long-term adverse effects, including cardiac toxicity. Although studies have reported associations between genetic variants and cardiorespiratory fitness, none has been performed on childhood ALL survivors. We performed whole-exome sequencing in 239 childhood ALL survivors from the PETALE cohort. Germline variants (both common and rare) in selected set of genes (N = 238) were analyzed for an association with cardiorespiratory fitness. Our results showed that the common variant in the TTN gene was significantly associated with a low cardiorespiratory fitness level (p = 0.0005) and that the LEPR, IGFBPI and ENO3 genes were significantly associated with a low cardiorespiratory fitness level in female survivors (p ≤ 0.002). Also, we detected an association between the low cardiorespiratory fitness level in participants that were stratified to the “high risk” prognostic group and functionally predicted rare variants in the SLC22A16 gene (p = 0.001). Positive associations between cardiorespiratory fitness level and trainability genes were mainly observed in females. For the first time, we observed that low cardiorespiratory fitness in childhood ALL survivors can be associated with variants in genes related to subjects’ trainability. These findings could allow better childhood ALL patient follow-up tailored to their genetic profile and cardiorespiratory fitness, which could help reduce at least some of the burden of long-term adverse effects of treatments." @default.
- W2946018920 created "2019-05-29" @default.
- W2946018920 creator A5006794446 @default.
- W2946018920 creator A5010481627 @default.
- W2946018920 creator A5026291256 @default.
- W2946018920 creator A5027608352 @default.
- W2946018920 creator A5028383766 @default.
- W2946018920 creator A5035824049 @default.
- W2946018920 creator A5039922554 @default.
- W2946018920 creator A5043333818 @default.
- W2946018920 creator A5065889241 @default.
- W2946018920 creator A5070491669 @default.
- W2946018920 creator A5085557593 @default.
- W2946018920 creator A5089503212 @default.
- W2946018920 date "2019-05-14" @default.
- W2946018920 modified "2023-10-18" @default.
- W2946018920 title "Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors" @default.
- W2946018920 cites W1563940013 @default.
- W2946018920 cites W1822286406 @default.
- W2946018920 cites W1943795552 @default.
- W2946018920 cites W1967940363 @default.
- W2946018920 cites W1972467214 @default.
- W2946018920 cites W1972904187 @default.
- W2946018920 cites W1973780680 @default.
- W2946018920 cites W1980740976 @default.
- W2946018920 cites W1984068087 @default.
- W2946018920 cites W2002193164 @default.
- W2946018920 cites W2014404137 @default.
- W2946018920 cites W2019740701 @default.
- W2946018920 cites W2022229829 @default.
- W2946018920 cites W2023126822 @default.
- W2946018920 cites W2031235345 @default.
- W2946018920 cites W2032704747 @default.
- W2946018920 cites W2036907814 @default.
- W2946018920 cites W2037777724 @default.
- W2946018920 cites W2038840993 @default.
- W2946018920 cites W2038963685 @default.
- W2946018920 cites W2040704764 @default.
- W2946018920 cites W2041663954 @default.
- W2946018920 cites W2042197418 @default.
- W2946018920 cites W2044353077 @default.
- W2946018920 cites W2054854056 @default.
- W2946018920 cites W2057850545 @default.
- W2946018920 cites W2058337944 @default.
- W2946018920 cites W2065834981 @default.
- W2946018920 cites W2066028007 @default.
- W2946018920 cites W2073828305 @default.
- W2946018920 cites W2083288537 @default.
- W2946018920 cites W2085568044 @default.
- W2946018920 cites W2085592929 @default.
- W2946018920 cites W2105381419 @default.
- W2946018920 cites W2108234281 @default.
- W2946018920 cites W2109791231 @default.
- W2946018920 cites W2116163234 @default.
- W2946018920 cites W2118878272 @default.
- W2946018920 cites W2119180969 @default.
- W2946018920 cites W2121067536 @default.
- W2946018920 cites W2129038576 @default.
- W2946018920 cites W2129269117 @default.
- W2946018920 cites W2133304247 @default.
- W2946018920 cites W2146273335 @default.
- W2946018920 cites W2148924243 @default.
- W2946018920 cites W2152922562 @default.
- W2946018920 cites W2157176507 @default.
- W2946018920 cites W2157777847 @default.
- W2946018920 cites W2161082810 @default.
- W2946018920 cites W2161300547 @default.
- W2946018920 cites W2161633633 @default.
- W2946018920 cites W2162812015 @default.
- W2946018920 cites W2163953557 @default.
- W2946018920 cites W2169908720 @default.
- W2946018920 cites W2171777347 @default.
- W2946018920 cites W2317055602 @default.
- W2946018920 cites W2325815304 @default.
- W2946018920 cites W2399104839 @default.
- W2946018920 cites W2562472854 @default.
- W2946018920 cites W2564549830 @default.
- W2946018920 cites W2767282657 @default.
- W2946018920 cites W2770750538 @default.
- W2946018920 cites W2915256151 @default.
- W2946018920 cites W4251690959 @default.
- W2946018920 cites W51523625 @default.
- W2946018920 cites W88307321 @default.
- W2946018920 doi "https://doi.org/10.1186/s12885-019-5651-z" @default.
- W2946018920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6515640" @default.
- W2946018920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31088516" @default.
- W2946018920 hasPublicationYear "2019" @default.
- W2946018920 type Work @default.
- W2946018920 sameAs 2946018920 @default.
- W2946018920 citedByCount "8" @default.
- W2946018920 countsByYear W29460189202020 @default.
- W2946018920 countsByYear W29460189202021 @default.
- W2946018920 countsByYear W29460189202022 @default.
- W2946018920 crossrefType "journal-article" @default.
- W2946018920 hasAuthorship W2946018920A5006794446 @default.
- W2946018920 hasAuthorship W2946018920A5010481627 @default.
- W2946018920 hasAuthorship W2946018920A5026291256 @default.
- W2946018920 hasAuthorship W2946018920A5027608352 @default.
- W2946018920 hasAuthorship W2946018920A5028383766 @default.
- W2946018920 hasAuthorship W2946018920A5035824049 @default.