FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946020006> ?p ?o ?g. }

• W2946020006 abstract "ABSTRACT Efficient sensory processing requires that the brain is able to maximize its response to unexpected stimuli, while suppressing responsivity to expected events. Mismatch negativity (MMN) is an auditory event-related potential that occurs when a regular pattern is interrupted by an event that violates the expected properties of the pattern. MMN has been found to be reduced in individuals with schizophrenia in over 100 separate studies, an effect believed to be underpinned by glutamate N-methyl-D-aspartate receptor (NMDA-R) dysfunction, as it is observed that NMDA-R antagonists also reduce MMN in healthy volunteers. The aim of the current study is to examine this effect in rodents. Using single unit recording in specific auditory areas using methods not readily utilized in humans, we have previously demonstrated that neuronal indices of rodent mismatch responses recorded from thalamic and cortical areas of the brain can be decomposed into a relatively simple repetition suppression and a more sophisticated prediction error process. In the current study, we aimed to test how the NMDA-R antagonist, MK-801, affected both of these processes along the rat auditory thalamocortical pathway. We found that MK-801 had the opposite effect than expected, and enhanced thalamic repetition suppression and cortical prediction error. These single unit data correlate with the recordings of local field responses. Together with previous data, this study suggests that our understanding of the contribution of NMDA-R system to MMN generation is far from complete, and also has potential implications for future research in schizophrenia. Significance Statement In this study, we demonstrate that an NMDA-R antagonist, MK-801, differentially affects single neuron responses to auditory stimuli along the thalamocortical axis by increasing the response magnitude of unexpected events in the auditory cortex and intensifying the adaptation of responses to expected events in the thalamus. Thus, we provide evidence that NMDA-R antagonists alter the balance between prediction-error and repetition suppression processes that underlie the generation of mismatch responses in the brain, and these effects are differentially expressed at different levels of auditory processing. As effects of MK-801 were in the opposite direction to our expectations, it demonstrates that our understanding of role of NMDA-R in synaptic plasticity and the neural processes underpinning MMN generation are far from complete." @default.
• W2946020006 created "2019-05-29" @default.
• W2946020006 creator A5010001127 @default.
• W2946020006 creator A5044550011 @default.
• W2946020006 creator A5049430041 @default.
• W2946020006 creator A5054926075 @default.
• W2946020006 creator A5065566980 @default.
• W2946020006 date "2019-05-12" @default.
• W2946020006 modified "2023-09-26" @default.
• W2946020006 title "The effect of NMDA-R antagonist, MK-801, on neuronal mismatch along the auditory thalamocortical pathway" @default.
• W2946020006 cites W1590457702 @default.
• W2946020006 cites W1835009446 @default.
• W2946020006 cites W1970448316 @default.
• W2946020006 cites W1973927342 @default.
• W2946020006 cites W1981234599 @default.
• W2946020006 cites W1982278227 @default.
• W2946020006 cites W1991255970 @default.
• W2946020006 cites W1992145070 @default.
• W2946020006 cites W1995852935 @default.
• W2946020006 cites W1996141026 @default.
• W2946020006 cites W2001351860 @default.
• W2946020006 cites W2006749341 @default.
• W2946020006 cites W2026521162 @default.
• W2946020006 cites W2034779270 @default.
• W2946020006 cites W2049328501 @default.
• W2946020006 cites W2055970280 @default.
• W2946020006 cites W2057929164 @default.
• W2946020006 cites W2071199266 @default.
• W2946020006 cites W207132095 @default.
• W2946020006 cites W2073905083 @default.
• W2946020006 cites W2075113080 @default.
• W2946020006 cites W2076231092 @default.
• W2946020006 cites W2091222268 @default.
• W2946020006 cites W2094000243 @default.
• W2946020006 cites W2095308610 @default.
• W2946020006 cites W2105732570 @default.
• W2946020006 cites W2109848582 @default.
• W2946020006 cites W2120687792 @default.
• W2946020006 cites W2127958135 @default.
• W2946020006 cites W2141943390 @default.
• W2946020006 cites W2142009972 @default.
• W2946020006 cites W2150174494 @default.
• W2946020006 cites W2154152979 @default.
• W2946020006 cites W2154183720 @default.
• W2946020006 cites W2154221773 @default.
• W2946020006 cites W2162105248 @default.
• W2946020006 cites W2172297511 @default.
• W2946020006 cites W2177522049 @default.
• W2946020006 cites W2178409791 @default.
• W2946020006 cites W2266468563 @default.
• W2946020006 cites W2287998060 @default.
• W2946020006 cites W2294264161 @default.
• W2946020006 cites W2341498450 @default.
• W2946020006 cites W2412875080 @default.
• W2946020006 cites W2461671056 @default.
• W2946020006 cites W2472945426 @default.
• W2946020006 cites W2586691160 @default.
• W2946020006 cites W2605250342 @default.
• W2946020006 cites W2608181477 @default.
• W2946020006 cites W2740567966 @default.
• W2946020006 cites W2754676563 @default.
• W2946020006 cites W2774201964 @default.
• W2946020006 cites W2787882030 @default.
• W2946020006 cites W2797071919 @default.
• W2946020006 cites W2803082720 @default.
• W2946020006 cites W2804048957 @default.
• W2946020006 cites W2806756628 @default.
• W2946020006 cites W2884619445 @default.
• W2946020006 cites W2888842486 @default.
• W2946020006 cites W2901597764 @default.
• W2946020006 cites W2911176868 @default.
• W2946020006 cites W787594251 @default.
• W2946020006 cites W795087190 @default.
• W2946020006 doi "https://doi.org/10.1101/636068" @default.
• W2946020006 hasPublicationYear "2019" @default.
• W2946020006 type Work @default.
• W2946020006 sameAs 2946020006 @default.
• W2946020006 citedByCount "0" @default.
• W2946020006 crossrefType "posted-content" @default.
• W2946020006 hasAuthorship W2946020006A5010001127 @default.
• W2946020006 hasAuthorship W2946020006A5044550011 @default.
• W2946020006 hasAuthorship W2946020006A5049430041 @default.
• W2946020006 hasAuthorship W2946020006A5054926075 @default.
• W2946020006 hasAuthorship W2946020006A5065566980 @default.
• W2946020006 hasBestOaLocation W29460200061 @default.
• W2946020006 hasConcept C118552586 @default.
• W2946020006 hasConcept C126322002 @default.
• W2946020006 hasConcept C15744967 @default.
• W2946020006 hasConcept C169760540 @default.
• W2946020006 hasConcept C170493617 @default.
• W2946020006 hasConcept C185263204 @default.
• W2946020006 hasConcept C21715850 @default.
• W2946020006 hasConcept C2776412080 @default.
• W2946020006 hasConcept C2776861996 @default.
• W2946020006 hasConcept C2780297895 @default.
• W2946020006 hasConcept C522805319 @default.
• W2946020006 hasConcept C61174792 @default.
• W2946020006 hasConcept C67018056 @default.
• W2946020006 hasConcept C71924100 @default.
• W2946020006 hasConcept C94487597 @default.

• next