Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946031037> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2946031037 abstract "Fibrinopeptide A (FPA) is frequently elevated in thromboembolism and DIC. As to the question which of the coagulation pathways (intrinsic vs extrinsic) is triggered under these conditions, measurement of FPA alone permits no answer. We measured both kallikrein (reflecting contact activation) and FPA in patients with classical DIC, established deep venous thrombosis (DVT) and pulmonary embolism (PE). Circulating kallikrein was measured as its capacity to generate bradykinin (BK) in whole blood (in the presence of kininase inhibitors) immediately after venipuncture. After incubation for 10 min. at room temp, kallikrein inhibitors were added. The increment of the BK concentration (ΔBK) -measured by radioimmunoassay- was used as marker of circulating kallikrein. The specificity and sensitivity of this method were superior to amidolytic assays for kallikrein. These data indicate the measurement of ΔBK is a potential tool to discriminate between intrinsic and extrinsic coagulation activation. In 2 patients with thromboembolism FPA normalised upon adequate anticogulant therapy, whereas ΔBK remained accerlerated for several weeks. This observation suggests that in these patients anticoagulant therapy was not adequate in eleminating the cause of coagulation activation. It is known that FPA is also frequently elevated in a variety of disorders not primarily associated with thrombosis or DIC. In 36 patients with chronic inflammatory diseases, FPA was elevated in 20 cases, whereas only in 1 patient ΔBK was accelerated (together with elevated FPA). We therefore conclude that the measurement of ΔBK is a more specific marker of intravascular coagulation activation, than the measurement of FPA." @default.
- W2946031037 created "2019-05-29" @default.
- W2946031037 creator A5002067357 @default.
- W2946031037 creator A5008512512 @default.
- W2946031037 creator A5033484583 @default.
- W2946031037 creator A5063117847 @default.
- W2946031037 creator A5065342241 @default.
- W2946031037 date "1981-01-01" @default.
- W2946031037 modified "2023-09-23" @default.
- W2946031037 title "Bradykinin Generation In Clinical Blood Samples: An Index Of Intrinsic Coagulation Activation" @default.
- W2946031037 doi "https://doi.org/10.1055/s-0038-1652052" @default.
- W2946031037 hasPublicationYear "1981" @default.
- W2946031037 type Work @default.
- W2946031037 sameAs 2946031037 @default.
- W2946031037 citedByCount "0" @default.
- W2946031037 crossrefType "proceedings-article" @default.
- W2946031037 hasAuthorship W2946031037A5002067357 @default.
- W2946031037 hasAuthorship W2946031037A5008512512 @default.
- W2946031037 hasAuthorship W2946031037A5033484583 @default.
- W2946031037 hasAuthorship W2946031037A5063117847 @default.
- W2946031037 hasAuthorship W2946031037A5065342241 @default.
- W2946031037 hasConcept C126322002 @default.
- W2946031037 hasConcept C136764020 @default.
- W2946031037 hasConcept C164705383 @default.
- W2946031037 hasConcept C170493617 @default.
- W2946031037 hasConcept C2777382242 @default.
- W2946031037 hasConcept C2778382381 @default.
- W2946031037 hasConcept C2779591629 @default.
- W2946031037 hasConcept C41008148 @default.
- W2946031037 hasConcept C71924100 @default.
- W2946031037 hasConceptScore W2946031037C126322002 @default.
- W2946031037 hasConceptScore W2946031037C136764020 @default.
- W2946031037 hasConceptScore W2946031037C164705383 @default.
- W2946031037 hasConceptScore W2946031037C170493617 @default.
- W2946031037 hasConceptScore W2946031037C2777382242 @default.
- W2946031037 hasConceptScore W2946031037C2778382381 @default.
- W2946031037 hasConceptScore W2946031037C2779591629 @default.
- W2946031037 hasConceptScore W2946031037C41008148 @default.
- W2946031037 hasConceptScore W2946031037C71924100 @default.
- W2946031037 hasLocation W29460310371 @default.
- W2946031037 hasOpenAccess W2946031037 @default.
- W2946031037 hasPrimaryLocation W29460310371 @default.
- W2946031037 hasRelatedWork W203684280 @default.
- W2946031037 hasRelatedWork W2080652668 @default.
- W2946031037 hasRelatedWork W2397715619 @default.
- W2946031037 hasRelatedWork W2404978365 @default.
- W2946031037 hasRelatedWork W2409828682 @default.
- W2946031037 hasRelatedWork W2415875367 @default.
- W2946031037 hasRelatedWork W2416169304 @default.
- W2946031037 hasRelatedWork W2416310522 @default.
- W2946031037 hasRelatedWork W2418260212 @default.
- W2946031037 hasRelatedWork W2419045687 @default.
- W2946031037 hasRelatedWork W2425750840 @default.
- W2946031037 hasRelatedWork W2434513072 @default.
- W2946031037 hasRelatedWork W2470166578 @default.
- W2946031037 hasRelatedWork W2470828446 @default.
- W2946031037 hasRelatedWork W2474343845 @default.
- W2946031037 hasRelatedWork W2694630673 @default.
- W2946031037 hasRelatedWork W310356777 @default.
- W2946031037 hasRelatedWork W2732106790 @default.
- W2946031037 hasRelatedWork W2754417375 @default.
- W2946031037 hasRelatedWork W2839149005 @default.
- W2946031037 isParatext "false" @default.
- W2946031037 isRetracted "false" @default.
- W2946031037 magId "2946031037" @default.
- W2946031037 workType "article" @default.