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• W2946034711 abstract "Cholinergic interneurons (CINs) are critical regulators of striatal network activity and output. Changes in CIN activity are thought to encode salient changes in the environment and stimulus–response–outcome associations. Here we report that the stress-associated neuropeptide corticotropin releasing factor (CRF) produces a profound and reliable increase in the spontaneous firing of CINs in both dorsal striatum and nucleus accumbens (NAc) through activation of CRF type 1 receptors, production of cAMP and reduction in spike accommodation in male mice. The increase of CIN firing by CRF results in the activation muscarinic acetylcholine receptors type 5, which mediate potentiation of dopamine transmission in the striatum. This study provides critical mechanistic insight into how CRF modulates striatal activity and dopamine transmission in the NAc to likely account for CRF facilitation of appetitive behaviors. <b>SIGNIFICANCE STATEMENT</b> Although the presence of CRF receptors in the dorsal and ventral striatum has been acknowledged, the cellular identity and the functional consequences of receptor activation is unknown. Here we report that striatal cholinergic interneurons express CRF-R1 receptors and are acutely activated by the neuropeptide CRF that is released in response to salient environmental stimuli. Cholinergic interneurons make <1% of the cells in the striatum but are critical regulators of the striatal circuitry and its output. CRF9s fast and potent activation of cholinergic interneurons could have far reaching behavioral implications across motivated behaviors controlled by the striatum." @default.
• W2946034711 created "2019-05-29" @default.
• W2946034711 creator A5019451739 @default.
• W2946034711 creator A5032065380 @default.
• W2946034711 creator A5082558170 @default.
• W2946034711 date "2019-05-20" @default.
• W2946034711 modified "2023-10-14" @default.
• W2946034711 title "Striatal Cholinergic Interneurons Are a Novel Target of Corticotropin Releasing Factor" @default.
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• W2946034711 doi "https://doi.org/10.1523/jneurosci.0479-19.2019" @default.
• W2946034711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6636075" @default.
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