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• W2946045667 abstract "Abstract Animal circadian rhythms persist in constant darkness and are driven by intracellular transcription-translation feedback loops. Although these cellular oscillators communicate, isolated mammalian cellular clocks continue to tick away in darkness without intercellular communication. To investigate these issues in Drosophila , we assayed behavior as well as molecular rhythms within individual brain clock neurons while blocking communication within the ca. 150 neuron clock network. We also generated CRISPR-mediated neuron-specific circadian clock knockouts. The results point to two key clock neuron groups: loss of the clock within both regions but neither one alone has a strong behavioral phenotype in darkness; communication between these regions also contributes to circadian period determination. Under these dark conditions, the clock within one region persists without network communication. The clock within the famous PDF-expressing s-LNv neurons however was strongly dependent on network communication, likely because clock gene expression within these vulnerable sLNvs depends on neuronal firing or light." @default.
• W2946045667 created "2019-05-29" @default.
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• W2946045667 date "2019-05-18" @default.
• W2946045667 modified "2023-09-23" @default.
• W2946045667 title "Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity" @default.
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• W2946045667 doi "https://doi.org/10.1101/639146" @default.
• W2946045667 hasPublicationYear "2019" @default.
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