FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946059722> ?p ?o ?g. }

• W2946059722 abstract "SRY‑box 9 (SOX9) is overexpressed in a number of human tumors, including gastric cancer (GC). However, the function of SOX9 in the development of GC remains unknown. In the present study, SOX9 activated the Hippo‑yes‑associated protein (YAP) signaling pathway to enhance the epithelial‑mesenchymal transition in GC cell lines. The results suggested that SOX9 knockdown inhibited invasion, proliferation and migration of GC cells. Furthermore, SOX9 silencing upregulated the expression of E‑cadherin, an epithelial marker, and downregulated the expression of mesenchymal markers, including snail family transcriptional repressor 1, vimentin and N‑cadherin. SOX9 overexpression increased the expression of the aforementioned markers. SOX9 significantly affected YAP phosphorylation and total YAP protein levels, suggesting that SOX9 is involved in the Hippo‑YAP signaling pathway. The current study revealed that SOX9 may be involved in the pathogenesis of GC, and further elucidation of the pathways involved may support the development of novel therapeutic options for the treatment of GC." @default.
• W2946059722 created "2019-05-29" @default.
• W2946059722 creator A5001821682 @default.
• W2946059722 creator A5004830405 @default.
• W2946059722 creator A5015782146 @default.
• W2946059722 creator A5018748052 @default.
• W2946059722 creator A5078176864 @default.
• W2946059722 date "2019-05-21" @default.
• W2946059722 modified "2023-10-16" @default.
• W2946059722 title "SOX9 promotes epithelial‑mesenchymal transition via the Hippo‑YAP signaling pathway in gastric carcinoma cells" @default.
• W2946059722 cites W1964081206 @default.
• W2946059722 cites W1969479669 @default.
• W2946059722 cites W1995160678 @default.
• W2946059722 cites W1996690536 @default.
• W2946059722 cites W2006645277 @default.
• W2946059722 cites W2008812172 @default.
• W2946059722 cites W2014260136 @default.
• W2946059722 cites W2015050458 @default.
• W2946059722 cites W2022584463 @default.
• W2946059722 cites W2028845278 @default.
• W2946059722 cites W2043857262 @default.
• W2946059722 cites W2064644124 @default.
• W2946059722 cites W2077151773 @default.
• W2946059722 cites W2104020201 @default.
• W2946059722 cites W2105772211 @default.
• W2946059722 cites W2107277218 @default.
• W2946059722 cites W2114643610 @default.
• W2946059722 cites W2132264180 @default.
• W2946059722 cites W2139979194 @default.
• W2946059722 cites W2148056172 @default.
• W2946059722 cites W2149168089 @default.
• W2946059722 cites W2154589460 @default.
• W2946059722 cites W2183386698 @default.
• W2946059722 cites W2192080449 @default.
• W2946059722 cites W2195552087 @default.
• W2946059722 cites W2199848035 @default.
• W2946059722 cites W2223413920 @default.
• W2946059722 cites W2280047579 @default.
• W2946059722 cites W2292376254 @default.
• W2946059722 cites W2304542741 @default.
• W2946059722 cites W2338586859 @default.
• W2946059722 cites W2406914149 @default.
• W2946059722 cites W2426003472 @default.
• W2946059722 cites W2549862740 @default.
• W2946059722 cites W2550941463 @default.
• W2946059722 cites W2558804565 @default.
• W2946059722 cites W2563337694 @default.
• W2946059722 cites W2567807354 @default.
• W2946059722 cites W2580966425 @default.
• W2946059722 cites W2587840780 @default.
• W2946059722 cites W2594762956 @default.
• W2946059722 cites W2615010141 @default.
• W2946059722 cites W2617783829 @default.
• W2946059722 cites W2619330317 @default.
• W2946059722 cites W2621447360 @default.
• W2946059722 cites W2625292750 @default.
• W2946059722 cites W2626081362 @default.
• W2946059722 cites W2626733097 @default.
• W2946059722 cites W2782227398 @default.
• W2946059722 cites W2783581317 @default.
• W2946059722 cites W2889069320 @default.
• W2946059722 cites W2890676899 @default.
• W2946059722 cites W2895520061 @default.
• W2946059722 cites W2898550269 @default.
• W2946059722 cites W2911197932 @default.
• W2946059722 cites W2911816659 @default.
• W2946059722 cites W2913445476 @default.
• W2946059722 cites W2921766926 @default.
• W2946059722 cites W2931790623 @default.
• W2946059722 cites W2938090289 @default.
• W2946059722 cites W2945535500 @default.
• W2946059722 cites W2976676649 @default.
• W2946059722 cites W2989699228 @default.
• W2946059722 cites W3023583695 @default.
• W2946059722 cites W2898413618 @default.
• W2946059722 doi "https://doi.org/10.3892/ol.2019.10387" @default.
• W2946059722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6546990" @default.
• W2946059722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31289532" @default.
• W2946059722 hasPublicationYear "2019" @default.
• W2946059722 type Work @default.
• W2946059722 sameAs 2946059722 @default.
• W2946059722 citedByCount "21" @default.
• W2946059722 countsByYear W29460597222019 @default.
• W2946059722 countsByYear W29460597222020 @default.
• W2946059722 countsByYear W29460597222021 @default.
• W2946059722 countsByYear W29460597222022 @default.
• W2946059722 countsByYear W29460597222023 @default.
• W2946059722 crossrefType "journal-article" @default.
• W2946059722 hasAuthorship W2946059722A5001821682 @default.
• W2946059722 hasAuthorship W2946059722A5004830405 @default.
• W2946059722 hasAuthorship W2946059722A5015782146 @default.
• W2946059722 hasAuthorship W2946059722A5018748052 @default.
• W2946059722 hasAuthorship W2946059722A5078176864 @default.
• W2946059722 hasBestOaLocation W29460597221 @default.
• W2946059722 hasConcept C104317684 @default.
• W2946059722 hasConcept C119056186 @default.
• W2946059722 hasConcept C121608353 @default.
• W2946059722 hasConcept C127561419 @default.
• W2946059722 hasConcept C147447768 @default.
• W2946059722 hasConcept C172512520 @default.

• next