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• W2946085003 endingPage "2085" @default.
• W2946085003 startingPage "2073" @default.
• W2946085003 abstract "New pyridine derivatives bearing p-dimethyl amino phenyl and p-bromophenyl moieties at position-4 and 6 have been prepared. The behavior of pyridone derivative 2 toward ethyl chloroacetate followed by hydrazine hydrate gave pyridinyl acetohydrazide derivative 7, and its behavior toward carbon electrophiles has been investigated by its reaction with aromatic aldehydes, ethyl acetoacetate, acetyl acetone, cyclohexanone, phthalic anhydride, maleic anhydride, and isatin affording the pyridine derivatives 8a–e to 16, respectively. Treatment of compound 2 with acrylonitrile in Et3N, yielded the N- alkylated derivative 17. Some pyrazole derivatives have been synthesized by interaction of the chalcone 1 with hydrazine hydrate afforded pyrazole derivative 18. Treatment of compound 18 with benzoyl chloride and or acetic anhydride resulted in the formation of the acylated compounds 19 and 20. Elemental and spectroscopic pieces of evidence characterized all the newly synthesized compounds. Some of the synthesized compounds were tested for their antibacterial activities against Gram-positive and Gram-negative bacteria." @default.
• W2946085003 created "2019-05-29" @default.
• W2946085003 creator A5050186251 @default.
• W2946085003 creator A5066000138 @default.
• W2946085003 date "2019-05-16" @default.
• W2946085003 modified "2023-09-23" @default.
• W2946085003 title "Synthesis and biological assessment of novel cyanopyridine derivatives" @default.
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• W2946085003 doi "https://doi.org/10.1080/00397911.2019.1616096" @default.
• W2946085003 hasPublicationYear "2019" @default.
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