Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946097773> ?p ?o ?g. }
- W2946097773 abstract "Abstract Lymphatic endothelial cells arise from the venous endothelial cells in embryonic lymphatic development. However, the molecular mechanisms remain to be elucidated. We here report that prostaglandin (PG) E 2 plays essential roles in the embryonic lymphatic development through the EP3 receptor, one of the PGE 2 receptors. Knockdown of the EP3 receptor or inhibition of cyclooxygenases (COX; rate-limiting enzymes for PG synthesis) impaired lymphatic development by perturbing lymphatic specification during zebrafish development. These impairments by COX inhibition were recovered by treatment with sulprostone (EP1/3 agonist). Knockdown of the EP3 receptor further demonstrated its requirement in the expression of sex determining region Y-box 18 (sox18) and nuclear receptor subfamily 2, group F, member 2 (nr2f2), essential factors of the lymphatic specification. The EP3 receptor was expressed in the posterior cardinal vein (region of embryonic lymphatic development) and the adjacent intermediate cell mass (ICM) during the lymphatic specification. COX1 was expressed in the region more upstream of the posterior cardinal vein relative to the EP3 receptor, and the COX1-selective inhibitor impaired the lymphatic specification. On the other hand, two COX2 subtypes did not show distinct sites of expression around the region of expression of the EP3 receptor. Finally, we generated EP3-deficient zebrafish, which also showed defect in lymphatic specification and development. Thus, we demonstrated that COX1-derived PGE 2 -EP3 pathway is required for embryonic lymphatic development by upregulating the expression of key factors for the lymphatic specification." @default.
- W2946097773 created "2019-05-29" @default.
- W2946097773 creator A5002852602 @default.
- W2946097773 creator A5004704949 @default.
- W2946097773 creator A5008472937 @default.
- W2946097773 creator A5015076659 @default.
- W2946097773 creator A5027546557 @default.
- W2946097773 creator A5047140034 @default.
- W2946097773 creator A5053545534 @default.
- W2946097773 creator A5057468423 @default.
- W2946097773 creator A5059925930 @default.
- W2946097773 creator A5080549102 @default.
- W2946097773 date "2019-05-21" @default.
- W2946097773 modified "2023-10-16" @default.
- W2946097773 title "Essential role of prostaglandin E2 and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis" @default.
- W2946097773 cites W1608435511 @default.
- W2946097773 cites W1956254370 @default.
- W2946097773 cites W1968038996 @default.
- W2946097773 cites W1968204605 @default.
- W2946097773 cites W1970549334 @default.
- W2946097773 cites W1979818342 @default.
- W2946097773 cites W1991506501 @default.
- W2946097773 cites W1992665817 @default.
- W2946097773 cites W2002318711 @default.
- W2946097773 cites W2008795770 @default.
- W2946097773 cites W2013253012 @default.
- W2946097773 cites W2033561781 @default.
- W2946097773 cites W2035415061 @default.
- W2946097773 cites W2037237890 @default.
- W2946097773 cites W2038236277 @default.
- W2946097773 cites W2044816418 @default.
- W2946097773 cites W2047526031 @default.
- W2946097773 cites W2050376918 @default.
- W2946097773 cites W2068166332 @default.
- W2946097773 cites W2084027198 @default.
- W2946097773 cites W2084544703 @default.
- W2946097773 cites W2091760375 @default.
- W2946097773 cites W2093604297 @default.
- W2946097773 cites W2096201131 @default.
- W2946097773 cites W2098874043 @default.
- W2946097773 cites W2099703857 @default.
- W2946097773 cites W2111015948 @default.
- W2946097773 cites W2111447897 @default.
- W2946097773 cites W2112006537 @default.
- W2946097773 cites W2116028999 @default.
- W2946097773 cites W2117588639 @default.
- W2946097773 cites W2120413309 @default.
- W2946097773 cites W2131515610 @default.
- W2946097773 cites W2151014103 @default.
- W2946097773 cites W2153339398 @default.
- W2946097773 cites W2154283619 @default.
- W2946097773 cites W2168245648 @default.
- W2946097773 cites W2169401708 @default.
- W2946097773 cites W2206057428 @default.
- W2946097773 cites W2301227733 @default.
- W2946097773 cites W2520965310 @default.
- W2946097773 cites W2529166335 @default.
- W2946097773 cites W2593643142 @default.
- W2946097773 doi "https://doi.org/10.1038/s41598-019-44095-5" @default.
- W2946097773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6529442" @default.
- W2946097773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31114004" @default.
- W2946097773 hasPublicationYear "2019" @default.
- W2946097773 type Work @default.
- W2946097773 sameAs 2946097773 @default.
- W2946097773 citedByCount "5" @default.
- W2946097773 countsByYear W29460977732019 @default.
- W2946097773 countsByYear W29460977732022 @default.
- W2946097773 countsByYear W29460977732023 @default.
- W2946097773 crossrefType "journal-article" @default.
- W2946097773 hasAuthorship W2946097773A5002852602 @default.
- W2946097773 hasAuthorship W2946097773A5004704949 @default.
- W2946097773 hasAuthorship W2946097773A5008472937 @default.
- W2946097773 hasAuthorship W2946097773A5015076659 @default.
- W2946097773 hasAuthorship W2946097773A5027546557 @default.
- W2946097773 hasAuthorship W2946097773A5047140034 @default.
- W2946097773 hasAuthorship W2946097773A5053545534 @default.
- W2946097773 hasAuthorship W2946097773A5057468423 @default.
- W2946097773 hasAuthorship W2946097773A5059925930 @default.
- W2946097773 hasAuthorship W2946097773A5080549102 @default.
- W2946097773 hasBestOaLocation W29460977731 @default.
- W2946097773 hasConcept C104317684 @default.
- W2946097773 hasConcept C121608353 @default.
- W2946097773 hasConcept C170493617 @default.
- W2946097773 hasConcept C173396325 @default.
- W2946097773 hasConcept C178592051 @default.
- W2946097773 hasConcept C181152851 @default.
- W2946097773 hasConcept C203014093 @default.
- W2946097773 hasConcept C2776636583 @default.
- W2946097773 hasConcept C2776878037 @default.
- W2946097773 hasConcept C2778938600 @default.
- W2946097773 hasConcept C2779013556 @default.
- W2946097773 hasConcept C2910366181 @default.
- W2946097773 hasConcept C502942594 @default.
- W2946097773 hasConcept C54355233 @default.
- W2946097773 hasConcept C55493867 @default.
- W2946097773 hasConcept C81885089 @default.
- W2946097773 hasConcept C86803240 @default.
- W2946097773 hasConcept C95444343 @default.
- W2946097773 hasConceptScore W2946097773C104317684 @default.
- W2946097773 hasConceptScore W2946097773C121608353 @default.