Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946173814> ?p ?o ?g. }
- W2946173814 endingPage "798" @default.
- W2946173814 startingPage "787" @default.
- W2946173814 abstract "Regulatory T cells (Tregs) continuously suppress autoreactive immune responses within tissues to prevent autoimmunity, yet the recirculatory behavior of Tregs between and within tissues enabling the maintenance of peripheral tolerance remains incompletely defined. Here, we quantified homing efficiency to and the dwell time of Tregs within secondary lymphoid organs (SLOs) and used intravital two-photon microscopy to measure Treg surveillance behavior of dendritic cells. Tregs homed substantially less efficiently to SLOs compared with conventional CD4+ T cells (Tconvs), despite similar expression of homing receptors. Tregs remained on average 2-3 times longer within the LN than Tconvs before exiting, and retained Tregs differed from recirculating Tregs in phenotype, motility and interaction duration with dendritic cells. Taken together, these data revealed fundamental differences in Treg versus conventional T cell in vivo recirculation and migration behaviors, identified a Treg population with prolonged LN dwell time, and provided quantitative insight into their spatiotemporal behavior within LNs." @default.
- W2946173814 created "2019-05-29" @default.
- W2946173814 creator A5012222945 @default.
- W2946173814 creator A5025536959 @default.
- W2946173814 creator A5038131981 @default.
- W2946173814 creator A5053568123 @default.
- W2946173814 creator A5056257036 @default.
- W2946173814 creator A5058109622 @default.
- W2946173814 creator A5059056583 @default.
- W2946173814 creator A5063978008 @default.
- W2946173814 creator A5065430468 @default.
- W2946173814 creator A5076710857 @default.
- W2946173814 creator A5088927850 @default.
- W2946173814 date "2019-06-17" @default.
- W2946173814 modified "2023-10-15" @default.
- W2946173814 title "Regulatory T cells differ from conventional CD 4 + T cells in their recirculatory behavior and lymph node transit times" @default.
- W2946173814 cites W1526518539 @default.
- W2946173814 cites W1543753614 @default.
- W2946173814 cites W1814637494 @default.
- W2946173814 cites W1966684157 @default.
- W2946173814 cites W1969162956 @default.
- W2946173814 cites W1977980568 @default.
- W2946173814 cites W1978073168 @default.
- W2946173814 cites W1988338839 @default.
- W2946173814 cites W1999227421 @default.
- W2946173814 cites W2002301651 @default.
- W2946173814 cites W2015310734 @default.
- W2946173814 cites W2022730942 @default.
- W2946173814 cites W2022855448 @default.
- W2946173814 cites W2031061214 @default.
- W2946173814 cites W2041356495 @default.
- W2946173814 cites W2042844150 @default.
- W2946173814 cites W2050841352 @default.
- W2946173814 cites W2051220005 @default.
- W2946173814 cites W2059148210 @default.
- W2946173814 cites W2069043306 @default.
- W2946173814 cites W2072116490 @default.
- W2946173814 cites W2076655821 @default.
- W2946173814 cites W2078775078 @default.
- W2946173814 cites W2094504982 @default.
- W2946173814 cites W2107111117 @default.
- W2946173814 cites W2110227493 @default.
- W2946173814 cites W2111740348 @default.
- W2946173814 cites W2116747506 @default.
- W2946173814 cites W2118533976 @default.
- W2946173814 cites W2124553778 @default.
- W2946173814 cites W2125921975 @default.
- W2946173814 cites W2127605217 @default.
- W2946173814 cites W2128106363 @default.
- W2946173814 cites W2132427916 @default.
- W2946173814 cites W2135799518 @default.
- W2946173814 cites W2138853264 @default.
- W2946173814 cites W2148226248 @default.
- W2946173814 cites W2149928606 @default.
- W2946173814 cites W2153070402 @default.
- W2946173814 cites W2155521069 @default.
- W2946173814 cites W2155779547 @default.
- W2946173814 cites W2160167330 @default.
- W2946173814 cites W2160311765 @default.
- W2946173814 cites W2161195685 @default.
- W2946173814 cites W2167895056 @default.
- W2946173814 cites W2171844613 @default.
- W2946173814 cites W2177188076 @default.
- W2946173814 cites W2401985889 @default.
- W2946173814 cites W2477894296 @default.
- W2946173814 cites W2509587195 @default.
- W2946173814 cites W2514175262 @default.
- W2946173814 cites W2534647638 @default.
- W2946173814 cites W2577764248 @default.
- W2946173814 cites W2582457239 @default.
- W2946173814 cites W2602367642 @default.
- W2946173814 cites W2777101704 @default.
- W2946173814 doi "https://doi.org/10.1111/imcb.12276" @default.
- W2946173814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31127976" @default.
- W2946173814 hasPublicationYear "2019" @default.
- W2946173814 type Work @default.
- W2946173814 sameAs 2946173814 @default.
- W2946173814 citedByCount "4" @default.
- W2946173814 countsByYear W29461738142020 @default.
- W2946173814 countsByYear W29461738142023 @default.
- W2946173814 crossrefType "journal-article" @default.
- W2946173814 hasAuthorship W2946173814A5012222945 @default.
- W2946173814 hasAuthorship W2946173814A5025536959 @default.
- W2946173814 hasAuthorship W2946173814A5038131981 @default.
- W2946173814 hasAuthorship W2946173814A5053568123 @default.
- W2946173814 hasAuthorship W2946173814A5056257036 @default.
- W2946173814 hasAuthorship W2946173814A5058109622 @default.
- W2946173814 hasAuthorship W2946173814A5059056583 @default.
- W2946173814 hasAuthorship W2946173814A5063978008 @default.
- W2946173814 hasAuthorship W2946173814A5065430468 @default.
- W2946173814 hasAuthorship W2946173814A5076710857 @default.
- W2946173814 hasAuthorship W2946173814A5088927850 @default.
- W2946173814 hasBestOaLocation W29461738141 @default.
- W2946173814 hasConcept C151872237 @default.
- W2946173814 hasConcept C181152851 @default.
- W2946173814 hasConcept C18903297 @default.
- W2946173814 hasConcept C203014093 @default.
- W2946173814 hasConcept C2777016536 @default.