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- W2946202214 abstract "Measurement of enzymatically-modified fibrinogen, fibrin, or related proteolysie products represent a means whereby the action of several enzymes can be quantiated both in vitro and in vivo. Advances in physicochemical techniques and in immunology over the past decade permit translation of recently acquired primary structural data on fibrinogen and fibrin into sensitive and specific assays for detecting derivatives of these proteins in the circulation. Physicochemical techniques that have been used by various investigators include paracoagulation tests, affinity chromatography, gel permeation chromatography, and electrophoresis. The limitations in specificity and sensitivity of these techniques in detecting circulating fibrin(ogen) derivatives is offset by the technical simplicity of most of these procedures, and perhaps these techniques in combination may ultimately yield useful clinical tests. Immunological tests can, in theory, offer vastly improved specificity and sensitivity as compared with the above mentioned procedures. However, preparation of immune reagents of high specificity is both tedious and difficult, usually requiring multiple adsorbtion steps to harvest the desired antibody population. Our recent studies on the immunochemistry of human fibrinopeptide B suggest that by restricting the size of the immunizing antigen, one can readily obtain antibodies which are relatively. restricted as determined by isoelectric focusing experiments, and which also offer great specificity. The potential for developing new antibody and T cell orobes into workable assays for detecting circulating fibrin(ogen) derivatives remains to be exolored." @default.
- W2946202214 created "2019-05-29" @default.
- W2946202214 creator A5084007242 @default.
- W2946202214 date "1979-01-01" @default.
- W2946202214 modified "2023-09-23" @default.
- W2946202214 title "Reflections of Fibrin Formation by In Vitro Testing" @default.
- W2946202214 doi "https://doi.org/10.1055/s-0039-1687483" @default.
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