FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946202457> ?p ?o ?g. }

• W2946202457 abstract "To successfully integrate a neuron into a circuit, a myriad of developmental events must occur correctly and in the correct order. Neurons must be born and grow out toward a destination, responding to guidance cues to direct their path. Once arrived, each neuron must segregate to the correct sub-region before sorting through a milieu of incorrect partners to identify the correct partner with which they can connect. Finally, the neuron must make a synaptic connection with their correct partner; a connection that needs to be broadly maintained throughout the life of the animal while remaining responsive to modes of plasticity and pruning. Though many intricate molecular mechanisms have been discovered to regulate each step, recent work showed that a single family of proteins, the Teneurins, regulates a host of these developmental steps in Drosophila - an example of biological adaptive reuse. Teneurins first influence axon guidance during early development. Once neurons arrive in their target regions, Teneurins enable partner matching and synapse formation in both the central and peripheral nervous systems. Despite these diverse processes and systems, the Teneurins use conserved mechanisms to achieve these goals, as defined by three tenets: (1) transsynaptic interactions with each other, (2) membrane stabilization via an interaction with and regulation of the cytoskeleton, and (3) a role for presynaptic Ten-a in regulating synaptic function. These processes are further distinguished by (1) the nature of the transsynaptic interaction - homophilic interactions (between the same Teneurins) to engage partner matching and heterophilic interactions (between different Teneurins) to enable synaptic connectivity and the proper apposition of pre- and postsynaptic sites and (2) the location of cytoskeletal regulation (presynaptic cytoskeletal regulation in the CNS and postsynaptic regulation of the cytoskeleton at the NMJ). Thus, both the roles and the mechanisms governing them are conserved across processes and synapses. Here, we will highlight the contributions of Drosophila synaptic biology to our understanding of the Teneurins, discuss the mechanistic conservation that allows the Teneurins to achieve common neurodevelopmental goals, and present new data in support of these points. Finally, we will posit the next steps for understanding how this remarkably versatile family of proteins functions to control multiple distinct events in the creation of a nervous system." @default.
• W2946202457 created "2019-05-29" @default.
• W2946202457 creator A5039846508 @default.
• W2946202457 creator A5043076954 @default.
• W2946202457 creator A5080424055 @default.
• W2946202457 date "2019-01-30" @default.
• W2946202457 modified "2023-09-28" @default.
• W2946202457 title "The Tenets of Teneurin: Conserved Mechanisms Regulate Diverse Developmental Processes in the Drosophila Nervous System" @default.
• W2946202457 cites W150635751 @default.
• W2946202457 cites W1509596764 @default.
• W2946202457 cites W1524619698 @default.
• W2946202457 cites W1528687531 @default.
• W2946202457 cites W1531234910 @default.
• W2946202457 cites W1533971869 @default.
• W2946202457 cites W1940372664 @default.
• W2946202457 cites W1968327773 @default.
• W2946202457 cites W1969436175 @default.
• W2946202457 cites W1970677652 @default.
• W2946202457 cites W1972968697 @default.
• W2946202457 cites W1976531392 @default.
• W2946202457 cites W1979333716 @default.
• W2946202457 cites W1980094138 @default.
• W2946202457 cites W1982096086 @default.
• W2946202457 cites W1983555571 @default.
• W2946202457 cites W1995498481 @default.
• W2946202457 cites W1995852110 @default.
• W2946202457 cites W2000983472 @default.
• W2946202457 cites W2012035454 @default.
• W2946202457 cites W2013895597 @default.
• W2946202457 cites W2014632617 @default.
• W2946202457 cites W2015043293 @default.
• W2946202457 cites W2023770618 @default.
• W2946202457 cites W2025721773 @default.
• W2946202457 cites W2026386725 @default.
• W2946202457 cites W2027650800 @default.
• W2946202457 cites W2027788106 @default.
• W2946202457 cites W2031075742 @default.
• W2946202457 cites W2033177418 @default.
• W2946202457 cites W2033712349 @default.
• W2946202457 cites W2038467257 @default.
• W2946202457 cites W2041238452 @default.
• W2946202457 cites W2044836636 @default.
• W2946202457 cites W2045756603 @default.
• W2946202457 cites W2051852715 @default.
• W2946202457 cites W2052799187 @default.
• W2946202457 cites W2059752598 @default.
• W2946202457 cites W2064424062 @default.
• W2946202457 cites W2066901336 @default.
• W2946202457 cites W2067738760 @default.
• W2946202457 cites W2071202857 @default.
• W2946202457 cites W2071207916 @default.
• W2946202457 cites W2072370858 @default.
• W2946202457 cites W2072730361 @default.
• W2946202457 cites W2078422108 @default.
• W2946202457 cites W2079878175 @default.
• W2946202457 cites W2085646162 @default.
• W2946202457 cites W2087404679 @default.
• W2946202457 cites W2089268791 @default.
• W2946202457 cites W2094458576 @default.
• W2946202457 cites W2098092575 @default.
• W2946202457 cites W2099348148 @default.
• W2946202457 cites W2109642486 @default.
• W2946202457 cites W2110254556 @default.
• W2946202457 cites W2115354701 @default.
• W2946202457 cites W2115699934 @default.
• W2946202457 cites W2122551650 @default.
• W2946202457 cites W2138879453 @default.
• W2946202457 cites W2141652419 @default.
• W2946202457 cites W2144131842 @default.
• W2946202457 cites W2157071511 @default.
• W2946202457 cites W2173497794 @default.
• W2946202457 cites W2202281942 @default.
• W2946202457 cites W2266968689 @default.
• W2946202457 cites W2325324774 @default.
• W2946202457 cites W2334466801 @default.
• W2946202457 cites W2502587315 @default.
• W2946202457 cites W2590822627 @default.
• W2946202457 cites W2593092078 @default.
• W2946202457 cites W2742439855 @default.
• W2946202457 cites W2754508573 @default.
• W2946202457 cites W2770408890 @default.
• W2946202457 cites W2787079193 @default.
• W2946202457 cites W2794174100 @default.
• W2946202457 cites W2799552888 @default.
• W2946202457 cites W2802853167 @default.
• W2946202457 cites W2806763352 @default.
• W2946202457 cites W2949501662 @default.
• W2946202457 cites W2950934007 @default.
• W2946202457 cites W2952656021 @default.
• W2946202457 doi "https://doi.org/10.3389/fnins.2019.00027" @default.
• W2946202457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6363694" @default.
• W2946202457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30760977" @default.
• W2946202457 hasPublicationYear "2019" @default.
• W2946202457 type Work @default.
• W2946202457 sameAs 2946202457 @default.
• W2946202457 citedByCount "12" @default.
• W2946202457 countsByYear W29462024572019 @default.
• W2946202457 countsByYear W29462024572020 @default.
• W2946202457 countsByYear W29462024572021 @default.
• W2946202457 countsByYear W29462024572022 @default.

• next